Objective To investigate the efficacy of Fuyang cupping therapy combined with western medicine in the treatment of chronic pelvic pain secondary to sequelae of pelvic inflammatory disease (SPID-CPP). Methods A total of 100 SPID-CPP patients admitted to our hospital from December 2024 to December 2025 were selected and divided into two groups randomly, each group had 50 cases. The control group was managed with oral ibuprofen; on this basis, the observation group received supplementary Fuyang cupping sessions. Both groups received treatment for 3 menstrual cycles. The scores of lower abdominal pain, lumbosacral pain, local sign score, an analysis was conducted to compare the TCM syndrome scores and quality of life scores of the two groups. Serum inflammatory factors [hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6)] and hemorheology indexes [erythrocyte sedimentation rate (ESR), fibrinogen (Fib), plasma viscosity] were detected in both groups, and the clinical response was assessed in each of the two groups. Results A markedly higher total effective rate was achieved in the observation group than in the control group (P<0.05). Post-treatment assessments revealed that the observation group had significantly reduced lower abdominal pain, lumbosacral pain, local sign, and TCM syndrome scores relative to the control group (P<0.05), while their quality of life score was markedly elevated (P<0.05). After treatment, the levels of serum hs-CRP, IL-6, ESR, Fib and plasma viscosity in the observation group were lower (P<0.05). Conclusion Fuyang cupping therapy assisted with western medicine exerts a significant efficacy in the treatment of SPID-CPP. It can more effectively alleviate pain, improve local symptoms, and its underlying mechanism may be related to reducing inflammation and improving hemorheology.