Chinese Core Science and Technology Journals
RCCSE Chinese Core Academic Journals
University Science and Technology Journals
High quality scientific and technological journals in universities
China Science and Technology Journal Excellence Initiative (Phase II
- Current Directory
- First Published
- Latest Recruitment
- Most Downloaded Archive
-
Policy optimization of TCM DRG payment reform based on intelligent sensitivity: A case study of the “Dual-Track” practice in Chongqing
Long for; Tang Junshu; Pan Jiangshan; Ouyang Weiwei; Luo Mei; Peng Meihua; Jiang Tao
2026,41(4):385-394 ,DOI: 10.3969/j.issn.1005-3697.2026.04.001
Abstract:
Objective: Addressing the compatibility issues between current Diagnosis-Related Group (DRG) payment rules and Traditional Chinese Medicine (TCM) clinical practice, this study focuses on the “dual-track” DRG practice in Chongqing. It aims to quantitatively map the core risk factors triggering DRG financial losses in different-tier TCM institutions through intelligent sensitivity testing, providing targeted empirical evidence for the differentiated optimization of medical insurance policies. Methods: A progressive research framework combining “macro-level empirical qualitative analysis and micro-level algorithmic simulation” was constructed. (1) Field research was conducted on 26 multi-tier TCM institutions in Chongqing via stratified random sampling to obtain baseline characteristics and execution pain points. (2) The Monte Carlo algorithm was introduced to generate a virtual micro-medical record dataset of 5,000 cases based on the surveyed macro-statistical distribution. (3) An intelligent sensitivity testing model based on the Random Forest algorithm was built with “whether a single case incurred a DRG settlement loss” as the dependent variable. This model quantitatively mapped the sensitivity (feature importance) of various clinical features causing losses under established rule constraints, with its efficacy verified by ROC curves and AUC values. Results: Chongqing’s “dual-track” reform had initially consolidated the positioning of grassroots TCM services, however, structural frictions persist at the micro-implementation level. The model’s sensitivity analysis revealed that tertiary hospitals were highly sensitive to the “TCM treatment rate” assessment, and their losses were primarily driven by the rigid reliance on modern medical interventions for severe cases (highest sensitivity contribution score). Conversely, secondary hospitals were highly sensitive to the “average length of stay,” where prolonged rehabilitation leading to fixed-quota cost inversion constitutes the core financial risk. Additionally, execution pain points such as the undervaluation of core TCM technologies were corroborated through field surveys. Conclusion: It is recommended to implement categorized optimization strategies based on the intelligent sensitivity test results: exploring flexible exemptions for the “TCM treatment rate” in specific intensive care departments and special-case negotiation mechanisms for tertiary hospitals; promoting a “DRG fixed quota + flexible bed-day” mixed payment model for secondary hospitals; and strengthening underlying data cross-system mapping and rational pricing mechanisms to further enhance the refinement and inclusivity of the TCM DRG payment system.
-
Implementation of an interactive chest CT image demonstration system based on unreal engine
HE Wen-jing;LI Bing;TAN Xue-feng;LIAO Qin-mei;ZENG Zhen;TAN Shi-han;LI Xin;CHEN Xiao-wen
2026,41(4):395-407 ,DOI: 10.3969/j.issn.1005-3697.2026.04.002
Abstract:
Objective: Traditional medical image visualization technologies present several limitations including the poor intuitiveness of 2D images, overlapping imaging blind spots, and insufficient interactivity. These shortcomings make them unable to satisfy the demands of precision medicine and medical education. This study aims to develop a universal medical image demonstration system based on extended reality (XR) technology, which is compatible with devices such as the HoloLens. By employing 3D visualization and multimodal interaction design, the system provides a more efficient and intuitive approach for clinical diagnosis, medical education, and surgical simulation. Methods: The system employs Unreal Engine as the core platform for architecture framework construction, supporting customized medical image visualization for XR devices. Real chest CT images were utilized in this study. Image segmentation was performed using 3D Slicer, while mask preprocessing was conducted via Anaconda. The masked images and raw data were then imported into Unreal Engine. The core framework of the proposed system was developed using Unreal Engine’s Blueprint visual scripting and Unreal Motion Graphics (UMG) interface designer. A self-directed learning assessment experiment was designed to evaluate the efficacy and performance of the system. Results: The experimental group achieved a pulmonary window recognition accuracy of 82%, a mediastinal window accuracy of 88%, and an overall accuracy of 85%. By comparison, the control group exhibited a pulmonary window accuracy of 50%, a mediastinal window accuracy of 44%, and an overall accuracy of 47%. Conclusions: The medically oriented imaging demonstration system significantly improves recognition accuracy and learning effectiveness, verifying its practical utility and validity.
-
Early prediction of acute pancreatitis-induced acute lung injury using a multimodal model based on dual-phase contrast-enhanced CT
Chen Shujun; Xiong Yuan; Song Xueliang; Deng Ping; Deng Hong; Zhang Xiaoming; Li Xinghui
2026,41(4):408-416 ,DOI: 10.3969/j.issn.1005-3697.2026.04.003
Abstract:
Objective: To develop a multimodal deep learning-radiomics-clinical (DRC) model based on abdominal dual-phase contrast-enhanced CT (CECT) for the early prediction of acute pancreatitis-associated acute lung injury/acute respiratory distress syndrome (AP-ALI/ARDS). Methods: 320 AP patients were enrolled and randomly divided into a training set (n=189) and an internal test set (n=81) in a 7∶3 ratio, with an additional external test set (n=50). Clinical data and CECT images acquired within 48 hours after admission were collected. Independent clinical risk factors were selected using Logistic regression. The pancreatic parenchyma was manually delineated on both arterial and portal venous phase images, from which radiomics and deep learning features were subsequently extracted and screened. The random forest algorithm was used to construct the clinical model, radiomics model, deep learning model, and DRC model, respectively. Model performance was evaluated and compared using receiver operating characteristic (ROC) curves, the DeLong test, calibration curves, and decision curve analysis (DCA). Results: Among the 320 AP patients, 109 (34.06%) developed AP-ALI/ARDS. AP severity and blood glucose level were identified as independent risk factors. 6 radiomics features and 19 deep learning features were ultimately selected. The DRC model demonstrated superior predictive performance, achieving areas under the ROC curve (AUCs) of 0.973, 0.934, and 0.920 in the training, internal test, and external test sets, respectively. The DeLong test indicated that the AUC of the DRC model was significantly higher than those of the clinical and radiomics models (P<0.05). Calibration curves demonstrated that the DRC model exhibited the best performance, and DCA showed that it provided a greater overall net benefit across most threshold probabilities compared to other models. Conclusion: The DRC model exhibits excellent performance for the early prediction of AP-ALI/ARDS and shows potential as decision-support tool to guide clinical intervention.
-
Radiomics has the potential to increase the diagnostic confidence of experienced clinicians in assessing ACRTI-RADS category 4 and 5 thyroid nodules
Wang Di; Liu Xiaoling; Yao Jiao; Qin Xiachuan
2026,41(4):417-421 ,DOI: 10.3969/j.issn.1005-3697.2026.04.004
Abstract:
Objective: To investigate the diagnostic value of radiomics in thyroid nodules of American College of Radiology-Thyroid Imaging Reporting and Data System (ACRTI-RADS) grades 4 and 5. Methods: A retrospective study of 221 patients with ACRTI-RADS grades 4 and 5 who underwent thyroidectomy was performed. The data on clinicopathological and ultrasound examinations of the patients were analyzed. The images were randomized into a training set and a validation set. MaZda, a software for calculating texture parameters in digitized images, was employed to manually outline the images and extract radiomics features. Features were filtered through the univariate Logistic analysis and LASSO method. The Logistic regression model, Bayes model and KNN model were trained using the selected texture features. Results: 314 radiomics features were extracted from each patient’s ultrasound image ROI using the MaZda software package. The use of LASSO further filtered five most significant features. The KNN model, based on these features, performed the best, with ROC values of 0.849 for the training group and 0.885 for the testing group, and accuracy rates of 0.779 and 0.761, respectively. Compared to readings by experienced radiologists, the KNN model demonstrated superior performance. Conclusion: The ultrasound omics model based on thyroid ultrasound, which is superior to experienced physician-performed ultrasound diagnosis, has shown outstanding performance in diagnosing thyroid ACR grade 4, 5 nodules and provided an effective reference for the identification of clinical routine ACR4, 5 nodules.
-
XGBoost-SHAP-based interpretable framework for the early identification of pulmonary nodules
2026,41(4):422-427 ,DOI: 10.3969/j.issn.1005-3697.2026.04.005
Abstract:
Objective: To achieve early identification of pulmonary nodules and visual interpretation of key variables through interpretable machine learning, and to facilitate precise prevention, control, early diagnosis and treatment of lung cancer. Methods: This study enrolled individuals at high risk of lung cancer and completed clinical screening. Their high-risk assessment data and imaging results were extracted. Participants were divided into high-risk and low-risk groups for pulmonary nodules based on China’s Lung Cancer Screening Standard (T/CPMA 013-2020). Variables with differences identified by univariate analysis were used as predictors, with pulmonary nodule grouping as the dependent variable, to construct an interpretable XGBoost-SHAP identification framework for early nodule detection and visual result interpretation. Results: A total of 644 high-risk individuals were included, with 199 (30.9%) in the high-risk pulmonary nodule group. The XGBoost model achieved an accuracy of 0.9146, sensitivity of 0.7587, specificity of 0.9843, F1-score of 0.8458, and AUC of 0.9741 for nodule grouping. SHAP analysis revealed that higher SHAP values—and thus increased risk of nodule enlargement—were associated with greater smoking intensity, exposure to secondhand smoke from colleagues/family, infrequent kitchen ventilation during cooking, excessive intake of processed foods, occupational exposure to asbestos/radon, insufficient intake of protein, fruits and vegetables, and manual labor occupation. Conclusion: The constructed interpretable framework performs well in early pulmonary nodule identification. Changes in nodule size are associated not only with traditional risk factors (e.g., smoking habits, secondhand smoke exposure, cooking fume exposure, occupational asbestos/radon exposure) but also with the participants’ dietary habits.
-
Design and validation of a high-compatibility, high-throughput fully automated molecular diagnostic platform
Liu Tianyu; Zhang Guanbin; Yan Zhi
2026,41(4):428-434 ,DOI: 10.3969/j.issn.1005-3697.2026.04.006
Abstract:
Objective: To address the issues of complex operations, time consumption, high laboratory costs in molecular diagnostic technology, and the impact of human factors on accuracy during sample processing, a high-compatibility and high-throughput fully automated molecular diagnostic platform was developed. Methods: The LabEasy 8,000 Fully Automated Molecular Diagnostic Platform was designed, integrating reagent preparation, nucleic acid extraction, and PCR amplification processes through modular design, equipped with an AI-assisted recognition system, and compatible with mainstream domestic PCR reagents. Results: The platform achieved a detection throughput of 8,000 tests per single assay within 24 hours and 2,400 concurrent tests for multiple assays. Validated by the Gentier 96R fully automated PCR analysis system, the detection deviation for Hepatitis B Virus (HBV) and Hepatitis C Virus (HCV) was less than 0.5 log IU/mL (100% detection rate), the intra-assay coefficient of variation (CV) was less than 5%, and the limit of detection (LOD) reached 10 IU/mL. Conclusion: The platform can effectively improve the efficiency and accuracy of molecular diagnosis, providing a technical reference for the development of domestic fully automated molecular diagnostic equipment.
-
Effects of robot-assisted gait training on lower limb motor function and cerebral hemodynamics in patients with severe hemiplegia
Wang Hanming; Wang Congxiao; Geng Jiujun; Tian Jian; Xue Yafeng; Wang Huan
2026,41(4):435-442 ,DOI: 10.3969/j.issn.1005-3697.2026.04.007
Abstract:
Objective: To investigate the effects of Lokomat robot-assisted gait training (RAGT) on lower limb motor function and cerebral hemodynamics in patients with severe hemiplegia based on conventional rehabilitation therapy. Methods: A total of 126 patients with severe hemiplegia were selected and divided into a control group (conventional rehabilitation therapy, n=69) and an observation group (conventional rehabilitation plus RAGT training, n=57) according to different rehabilitation methods. After propensity score matching, each group included 44 cases. Cerebral hemodynamics-related indicators, balance function and lower limb motor function scores, gait parameters, levels of angiopoietin-1 (Ang-1) and vascular endothelial growth factor (VEGF), and cerebral hemodynamics indicators including maximum blood flow velocity (Vmax), minimum blood flow velocity (Vmin), peripheral resistance (RV), and dynamic resistance (DR) were compared before treatment, at 2 weeks, and at 5 weeks of treatment. A difference-in-differences (DID) model was constructed to analyze changes in vascular active substances and cerebral hemodynamics indicators after treatment in patients with severe hemiplegia. Results: After treatment, the observation group showed higher scores than the control group in the Berg Balance Scale (P<0.001), Fugl-Meyer Assessment (P<0.001), Stroke Rehabilitation Motor Function Assessment Scale (P<0.001), as well as faster walking speed, longer step length, and higher step frequency (P<0.05). Ang-1 and VEGF levels in the observation group were higher than those in the control group (P<0.001). Vmax and Vmin were higher than in the control group, while RV and DR were lower than in the control group (P<0.05). DID model results showed that the group×time interaction had a significant effect on improving vascular active substances and cerebral hemodynamics indicators (P<0.05). Conclusion: On the basis of conventional rehabilitation therapy, adjunctive RAGT training has a favorable clinical therapeutic effect, significantly optimizes cerebral hemodynamics in patients with severe hemiplegia, promotes the secretion of substances related to angiogenesis, and markedly improves patients’ balance ability, lower limb motor function, and gait parameters.
-
Effects of Fuzheng Xiaozheng Decoction on ultrastructure and TERT expression in different subtypes of breast cancer cells
Qian Zhiyuan; Jiang Jiemin; Lin Yongzhong; Wu Yanghui; Lin Zengxuan
2026,41(4):443-448+468 ,DOI: 10.3969/j.issn.1005-3697.2026.04.008
Abstract:
Objective: To investigate the effects of Fuzheng Xiaozheng Decoction (FZXD) on the ultrastructure and telomerase reverse transcriptase (TERT) expression in different subtypes of breast cancer cells. Methods: Twelve SPF-grade female BALB/c mice (4 weeks old, 16–22 g) were acclimated for 1 week and randomized into high-, medium-, and low-dose FZXD groups and a saline group (60, 40, 20 g/kg FZXD or saline by gavage) to determine the optimal dose. A second cohort of 40 mice was randomized into FZXD alone, paclitaxel (PTX) alone, FZXD+PTX combination, and blank control groups (n=10 each). FZXD was given at 60 g/kg twice daily, PTX injected intraperitoneally at 10 mg/kg twice weekly, and the combination group received both regimens for 7 days. One hour after the last dose, blood was collected, serum separated, heat-inactivated, and sterile-filtered (0.22 μm). Drug-containing serum was used to treat breast cancer cells. Cell proliferation (CCK-8), ultrastructure (TEM), TERT mRNA (RT-qPCR), TERT protein (Western blot), and telomere length (RT-qPCR, T/S ratio) were assessed. Results: High-dose FZXD-medicated serum reduced breast cancer cell viability below 50% at 48 h. TEM showed swollen mitochondria with ruptured outer membranes, disordered cristae, cytoplasmic vacuolization, and disrupted plasma membranes in FZXD, PTX, and combination groups. All treatment groups exhibited reduced TERT mRNA/protein levels and shortened telomeres vs. control. Conclusion: Fuzheng Xiaozheng Decoction suppresses breast cancer progression by downregulating TERT expression.
-
Effect and mechanism of dapagliflozin on rats with pulmonary hypertension related to left heart failure based on the TGF-β/BMP signaling pathway
Li Na; Li Qian; Song Bei; Wang Xiufen; Gong Lihua
2026,41(4):449-456 ,DOI: 10.3969/j.issn.1005-3697.2026.04.009
Abstract:
Objective: To explore the effect of dapagliflozin on pulmonary vascular remodeling and cardiac function in rats with pulmonary hypertension related to left heart failure (PH-LHF) by regulating the bone morphogenetic protein (BMP)/transforming growth factor-β (TGF-β) signaling pathway. Methods: A PH-LHF rat model was established via transverse aortic constriction (TAC) surgery. Rats were randomized into five groups (n=15 each): sham operation, model, low-dose dapagliflozin (1 mg/kg, ig), high-dose dapagliflozin (3 mg/kg, ig), and pathway activator (3 mg/kg dapagliflozin + 10 mg/kg TGF-β activator SRI-011381, ig). After treatment, right ventricular systolic pressure (RVSP) and left ventricular ejection fraction (LVEF) were measured. Right heart catheterization assessed pulmonary hypertension. Pulmonary arteriole pathology was evaluated via HE staining (wall thickness ratio [WT], vascular area ratio [WA]). Victoria blue and Van Giessen staining detected vascular lesions. ELISA measured serum laminin (LN), hyaluronic acid (HA), TGF-β1, and hydroxyproline (HYP). Western blot analyzed TGF-β/BMP pathway proteins. Results: Compared with the sham group, the model group showed pulmonary arteriole thickening, lumen narrowing, lung injury, and elevated RVSP, mPAP, mRVP, WT, WA, collagen fibers, LN, HA, HYP, TGF-β1, p-Smad1/2/3 (P<0.05); LVEF, elastic fibers, and BMPR2 decreased (P<0.05). Low/high-dose dapagliflozin improved vascular remodeling, cardiac function, and fibrosis markers (P<0.05), with high-dose being superior (P<0.05). The pathway activator reversed dapagliflozin’s beneficial effects (P<0.05). Conclusion: Dapagliflozin improves pulmonary vascular remodeling, cardiac function, and fibrosis in PH-LHF rats, likely via inhibiting the TGF-β/BMP pathway.
-
Expression and clinical significance of BAFF and APRIL in systemic sclerosis
2026,41(4):457-462 ,DOI: 10.3969/j.issn.1005-3697.2026.04.010
Abstract:
Objective: To investigate the expression levels and clinical significance of B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) in peripheral blood mononuclear cells (PBMCs) and plasma of patients with systemic sclerosis (SSc). Methods: Peripheral blood samples were collected from 32 SSc patients (SSc group) and 32 healthy controls (HC group). PBMCs and plasma were isolated and extracted. The mRNA and protein expression levels of BAFF and APRIL in PBMCs were detected using real-time quantitative PCR (RT-qPCR) and Western blot, respectively. Plasma concentrations of the corresponding proteins were measured by ELISA. Correlations with clinical indicators were analyzed, and the diagnostic value for SSc was evaluated using receiver operating characteristic (ROC) curves. Results: Both mRNA and protein expression levels of BAFF and APRIL in PBMCs of SSc patients were higher than those in the HC group (P<0.05). Plasma BAFF levels were positively correlated with erythrocyte sedimentation rate (r=0.60), high-sensitivity C-reactive protein (r=0.40), anti-Scl-70 antibody (r=0.57), and joint involvement (r=0.39) (P<0.05), and negatively correlated with estimated glomerular filtration rate (r=-0.37) (P<0.05). APRIL levels were positively correlated with interstitial lung disease (r=0.52) and high-density lipoprotein (r=0.45) (P<0.05). The areas under the ROC curve (AUC) for diagnosing SSc using BAFF, APRIL, and their combination were 0.759, 0.654, and 0.792, respectively. Conclusion: The expression of BAFF and APRIL is elevated in SSc patients and closely associated with specific autoantibodies, inflammatory status, and organ damage. Combined detection of both markers may improve the diagnostic efficacy for SSc, suggesting their potential as biomarkers and therapeutic targets for SSc.
-
Effects of SGLT2 inhibitors on heart rate variability and subclinical myocardial injury in elderly patients with type 2 diabetes mellitus and hypertension
Yu Yan; Cai Fengrong; Weng Youfei; Cai Lei; Feng Qian
2026,41(4):463-468 ,DOI: 10.3969/j.issn.1005-3697.2026.04.011
Abstract:
Objective: To investigate the effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors on heart rate variability and subclinical myocardial injury in elderly patients with type 2 diabetes mellitus (T2DM) and hypertension. Methods: A total of 102 elderly patients with T2DM and hypertension were enrolled and divided into an observation group and a control group, with 51 patients in each group, according to different treatment regimens. The control group received routine basic treatment, while the observation group received empagliflozin in addition to routine basic treatment. After 6 months of treatment, the two groups were compared in terms of blood pressure and blood glucose levels, standard deviation of normal RR intervals (SDNN), root mean square of successive differences of adjacent normal RR intervals (RMSSD), low-frequency power (LF), high-frequency power (HF), LF/HF ratio, left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI), ratio of early to late diastolic mitral inflow velocity (E/A), N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin I (hs-cTnI), glutathione peroxidase (GSH-Px), catalase (CAT), malondialdehyde (MDA), levels of TLR4/NF-κB signaling pathway-related indicators, and the occurrence of adverse events. Results: After treatment, systolic and diastolic blood pressure in the observation group were lower than those in the control group (P<0.05); fasting blood glucose, 2-hour postprandial blood glucose, and glycated hemoglobin were all lower in the observation group than in the control group (P<0.05). SDNN, RMSSD, LF, and HF were all higher in the observation group than in the control group (P<0.05), and the LF/HF ratio was lower in the observation group than in the control group (P<0.05). There was no statistically significant difference in LVEF between the two groups after treatment (P>0.05). LVMI was lower in the observation group than in the control group (P<0.05), and E/A was higher in the observation group than in the control group (P<0.05). Serum hs-cTnI and NT-proBNP levels were lower in the observation group than in the control group (P<0.05); serum GSH-Px and CAT levels were higher in the observation group than in the control group (P<0.05), and MDA levels were lower in the observation group than in the control group (P<0.05). The mRNA expression levels of TLR4, NF-κB, IL-1β, IL-6, and TNF-α were all lower in the observation group than in the control group (P<0.05). There was no statistically significant difference in the incidence of adverse events between the two groups (P>0.05). Conclusion: The combined use of the SGLT2 inhibitor empagliflozin can improve blood pressure and blood glucose control in elderly patients with T2DM and hypertension, optimize cardiac autonomic nerve regulation, reduce subclinical myocardial injury, inhibit oxidative stress response, and downregulate TLR4/NF-κB pathway-mediated inflammatory response.
-
Effect of modified Chaihu Guizhi Longgu Muli decoction on psychological status and sleep in patients with liver depression and qi stagnation type of insomnia
Bai Jie; Li Min; Wang Pei; Zang Dongjing
2026,41(4):469-472 ,DOI: 10.3969/j.issn.1005-3697.2026.04.012
Abstract:
Objective: To observe the effect of modified Chaihu Guizhi Longgu Muli decoction on the psychological status and sleep in patients with liver depression and qi stagnation type of insomnia. Methods: A total of 144 patients with insomnia of liver depression and qi stagnation type were selected and divided into two groups according to treatment methods: the control group (n=72) received conventional Western medicine treatment, while the treatment group (n=72) was treated with modified Chaihu Guizhi Longgu Muli decoction. Both groups were treated for 4 weeks. The clinical efficacy, TCM syndrome scores, psychological status (Hamilton Depression Scale [HAMD] and Hamilton Anxiety Scale [HAMA] scores), sleep quality (Pittsburgh Sleep Quality Index [PSQI], Insomnia Severity Index [ISI] scores), serum neurotransmitters (cortisol [Cor], epinephrine [E]) before and after treatment, and incidence of adverse reactions were compared between the two groups. Results: The overall response rate in the treatment group was higher than that in the control group (P<0.05). After 4 weeks of treatment, the scores of TCM syndromes, PSQI, ISI, HAMD, and HAMA in both groups were decreased compared with those before treatment, and the treatment group showed lower scores (P<0.05). The levels of Cor and E in both groups at 4 weeks of treatment were decreased compared with those before treatment, and the treatment group showed lower levels (P<0.05). The incidence of adverse reactions in the treatment group was lower than that in the control group (P<0.05). Conclusion: Modified Chaihu Guizhi Longgu Muli decoction can effectively regulate psychological status and sleep in patients with insomnia of liver depression and qi stagnation type, with few adverse reactions and high safety.
-
The efficacy, safety and impact on the risk of postoperative caries in severely young children under general anesthesia
Cao Liting; Xu Jie; Huang Ting; Wang Lingtong; Bai Bin
2026,41(4):473-477 ,DOI: 10.3969/j.issn.1005-3697.2026.04.013
Abstract:
Objective: To explore the efficacy and safety of general anesthesia for children with severe early childhood caries (S-ECC) and its impact on postoperative caries risk. Methods: A total of 260 children with S-ECC were enrolled and divided into a general anesthesia group (n=156) and a control group (n=104) based on treatment methods. The general anesthesia group received dental treatment under general anesthesia, while the control group was treated under protective immobilization. Oral hygiene, dietary habits, oral health-related quality of life (assessed via the Chinese version of the Early Childhood Oral Health Impact Scale [ECOHIS]), and caries susceptibility (detected using the Cariostat system) were compared between the two groups before and 1 month after treatment to evaluate caries risk. Results: One month post-treatment, the proportions of children brushing teeth morning and evening, using fluoride toothpaste, and brushing for ≥2 minutes increased significantly in both groups (P<0.05), with the control group showing higher adherence than the general anesthesia group (P<0.05). No significant changes were observed in dietary habits (e.g., sweetened beverage/dessert intake >1 time/day) post-treatment (P>0.05). Both groups exhibited reduced plaque index and Cariostat scores (P<0.05), with the general anesthesia group showing lower values than the control group (P<0.05). ECOHIS scores (child impact: oral function, symptoms, psychological/social relationships; family impact: parental guilt, economic burden) decreased significantly post-treatment (P<0.05), with the general anesthesia group demonstrating lower scores than the control group (P<0.05). Conclusion: General anesthesia is safe and effective for treating S-ECC in children. It improves short-term oral conditions, reduces caries risk, and enhances quality of life. However, postoperative oral health education should be strengthened to promote long-term healthy oral hygiene habits.
-
Correlation between gut microbiota dysbiosis and histological activity grading in patients with ulcerative colitis
Zhai Weichun; Ma Xiangzhi; Zhang Tianjin; Zhao Jiaojiao; Cheng Jianrong; Zhang Jiucong
2026,41(4):478-481 ,DOI: 10.3969/j.issn.1005-3697.2026.04.014
Abstract:
Objective: To investigate the correlation between gut microbiota dysbiosis and histological activity grading in patients with ulcerative colitis (UC). Methods: A total of 120 patients with UC were enrolled. According to the Nancy histological index, patients were divided into a mild activity group (score 2, n=58) and a severe activity group (score 4, n=62). Scores of crypt abscesses, inflammatory cell infiltration, glandular destruction, and composite histological severity were compared between the two groups. 16S rRNA sequencing data were used to quantify the relative abundance of key bacterial taxa: Firmicutes, Proteobacteria, Faecalibacterium, Bifidobacterium, and Escherichia?Shigella. Spearman correlation analysis was performed to assess associations between major taxa and inflammatory indicators, including C?reactive protein (CRP), erythrocyte sedimentation rate (ESR), Mayo clinical activity index (Mayo score), and composite histological score. Results: Compared with the mild group, the severe group had lower hemoglobin and albumin (P<0.05), higher white blood cell and platelet counts, CRP, ESR, and positive fecal occult blood (all P<0.05). Histologically, the severe group showed higher scores for crypt abscesses, inflammation, glandular destruction, and composite severity (P<0.001). Microbiota analysis revealed lower Firmicutes, Faecalibacterium, and Bifidobacterium, but higher Proteobacteria and Escherichia?Shigella in severe disease (P<0.05). Escherichia?Shigella correlated positively with CRP, ESR, Mayo score, and composite histological score (P<0.01). Faecalibacterium showed moderate negative correlations with these indicators (P<0.05), and Bifidobacterium showed mild?to?moderate negative correlations with CRP, Mayo score, and composite histological score (P<0.01). Conclusion: Distinct gut microbiota profiles exist across UC histological activity grades. Severe activity is characterized by enriched pathobionts (Escherichia?Shigella, Proteobacteria) and depleted beneficial taxa (Faecalibacterium, Bifidobacterium). Consistent correlations between bacterial taxa and inflammatory/histological indicators suggest gut microbiota features may serve as potential microbial markers reflecting mucosal inflammation severity in UC, providing valuable references for disease assessment.
-
Effects of feeding methods on dynamic changes of intestinal flora in infants based on metagenomics sequencing
Lin Yan; Lu Meiqin; Kong Wanning
2026,41(4):482-487 ,DOI: 10.3969/j.issn.1005-3697.2026.04.015
Abstract:
Objective: To analyze the effects of feeding methods on dynamic changes of intestinal flora in infants by metagenomics sequencing. Methods: A total of 60 normal full-term neonates delivered in the Obstetrics Department were enrolled. According to different feeding methods, they were divided into a breastfeeding group (n=23) and a formula feeding group (n=37). Total fecal DNA was extracted, sequenced, and analyzed using a high-throughput sequencing platform. The effects of different feeding methods on the establishment and development of intestinal flora in infants were compared. Results: There was no significant difference in Alpha diversity and Beta diversity of intestinal flora between the formula feeding group and the breastfeeding group (P>0.05). At 3 and 12 months of age, the relative abundance of Firmicutes C was higher in the breastfeeding group than in the formula feeding group (P<0.05). At 3 months of age, the relative abundance of Veillonella was higher in the breastfeeding group than in the formula feeding group (P<0.05). At different ages, there was no significant difference in the relative abundance of different dominant bacteria at the species level between the two groups (P>0.05). Conclusion: Feeding methods have certain effects on the evolution and development of intestinal flora in infants. Among them, breastfeeding is more conducive to the establishment of high-abundance intestinal flora and the normal development of intestinal flora.
-
Changes and correlation analysis of cognitive function and brain fractional amplitude of low frequency fluctuation in children with first-episode unmedicated attention deficit and hyperactivity disorder
Bai Yuchen; Huang Huanhuan; He Fan
2026,41(4):488-491 ,DOI: 10.3969/j.issn.1005-3697.2026.04.016
Abstract:
Objective: To explore the changes and correlation of brain fractional amplitude of low frequency fluctuation (fALFF) and cognitive function in children with first-episode unmedicated attention deficit and hyperactivity disorder (ADHD). Methods: The case data of 46 children with first-episode unmedicated ADHD were retrospectively analyzed and included in the observation group, and 42 healthy children undergoing physical examination during the same period were selected as the control group. The differences in cognitive function (completed category count, persistent response count, persistent error count, and error response count of Wisconsin Card Sorting Test (WCST), and error rate of interference response inhibition evaluated by Simon task) and fALFF in brain regions were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between cognitive function and fALFF in abnormal brain regions in children with ADHD. Results: Compared with the control group, the observation group had a lower completed category count, and higher persistent response count, persistent error count, error response count and interference response inhibition error rate (P<0.05). Compared with the control group, the fALFF values in the left superior postcentral gyrus and the right medial superior temporal gyrus were decreased in the observation group, while the fALFF values in the left caudate nucleus, posterior cingulate gyrus and right superior temporal gyrus were increased (P<0.05). Pearson correlation analysis showed that fALFF values in the left superior postcentral gyrus and right medial superior temporal gyrus of ADHD children were negatively correlated with error rate of interference response inhibition (P<0.05). Conclusion: There is a certain correlation between cognitive function changes and brain fALFF in children with first-episode unmedicated ADHD, and cognitive impairment may be related to abnormal changes in brain regions.
-
Effect of external application of Daxusong plaster combined with acupuncture therapy in treating knee osteoarthritis and the impact on serum indexes and pain
Li Hongxiang; Gong Qingguo; Ma Wenjie
2026,41(4):492-496 ,DOI: 10.3969/j.issn.1005-3697.2026.04.017
Abstract:
Objective: To explore the effect of external application of Daxusong plaster combined with acupuncture therapy in treating knee osteoarthritis and the impact on serum indexes and pain. Methods: According to the treatment plan, 120 patients with knee osteoarthritis were divided into the acupuncture group (conventional acupuncture) and the treatment group (acupuncture combined with external application of Daxusong plaster), with 60 cases in each group. The efficacy, TCM syndrome scores, serum indexes [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), cartilage oligomeric matrix protein (COMP), C-terminal cross-linked telopeptide of type II collagen (CTX-II), receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG)], pain degree [Visual Analog Scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)], and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate and OPG level in the treatment group were higher than those in the acupuncture group (P<0.05), while TCM syndrome scores, VAS scores, WOMAC, IL-6, TNF-α, COMP, CTX-II, and RANKL were lower than those in the acupuncture group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: External application of Daxusong plaster combined with acupuncture is effective in treating KOA (cold-dampness obstruction syndrome), which can effectively alleviate clinical symptoms and pain, improve inflammation and bone metabolism, and has good safety.
-
Relationship between serum diamine oxidase, serum-ascites albumin gradient levels and liver function, and disease severity in patients with cirrhosis and ascites
Zhang Donghong; Yuan Chen; Wu Xinglei
2026,41(4):497-500 ,DOI: 10.3969/j.issn.1005-3697.2026.04.018
Abstract:
Objective To investigate the relationship between serum diamine oxidase (DAO), serum-ascites albumin gradient (SAAG) levels and liver function, and disease severity in patients with cirrhosis and ascites.Methods The clinical data of 207 patients with cirrhosis and ascites were retrospectively analyzed. According to the tertiles of DAO, patients were divided into DAO1, DAO2, and DAO3 groups. According to the tertiles of SAAG, patients were divided into SAAG1, SAAG2, and SAAG3 groups. Based on Model for End-Stage Liver Disease (MELD) scores, patients were divided into high MELD score group (≥13) and low MELD score group (<13). Liver function indicators [serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL)], DAO, and SAAG levels were compared between groups. Pearson’s correlation was used to analyze the correlation between DAO/SAAG and liver function indicators. Multivariate Logistic regression analysis was used to analyze the relationship between DAO/SAAG and MELD score.Results There were significant differences in serum ALT, AST, and TBIL levels among patients with different DAO and SAAG levels (P<0.05). DAO and SAAG levels were positively correlated with ALT, AST, and TBIL levels (P<0.05). The high MELD score group had higher serum DAO and SAAG levels than the low MELD score group (P<0.05). Elevated DAO and SAAG levels were influencing factors of high MELD score (P<0.05).Conclusion Serum DAO and SAAG levels are correlated with liver function indicators in patients with cirrhosis and ascites. The two may be influencing factors of disease severity.
-
Transesophageal echocardiography for evaluating the immediate effects of prone position ventilation on right ventricular-pulmonary arterial coupling and right heart function in patients with ARDS complicated by shock and its prognostic value
Liu Yi; Yu Di; Li Ning; Yan Lijing; Wang Xin; Niu Yanhui
2026,41(4):501-505 ,DOI: 10.3969/j.issn.1005-3697.2026.04.019
Abstract:
Objective: To evaluate the immediate effects of prone position ventilation (PPV) on right ventricular-pulmonary arterial coupling (RV-PA) and right heart function in patients with acute respiratory distress syndrome (ARDS) complicated by shock using transesophageal echocardiography (TEE), and to analyze its relationship with prognosis. Methods: A total of 110 patients with ARDS complicated by shock who received PPV were enrolled as subjects. For all patients, TEE was used to monitor right heart function indicators before PPV (supine position) and 1 hour after PPV. These indicators included tricuspid annular plane systolic excursion (TAPSE), right ventricular fractional area change (RVFAC), and pulmonary artery systolic pressure (PASP). The TAPSE/PASP ratio was calculated to assess RV-PA coupling. Hemodynamic parameters, oxygenation indices before and after treatment, and 28-day mortality were also recorded. Results: At 1 hour after PPV, the patients' oxygenation index (PaO?/FiO?) improved (P<0.05). Right heart function indicators RVFAC and TAPSE increased (P<0.05), while PASP and right ventricular myocardial performance index (RMPI) decreased (P<0.05). The TAPSE/PASP ratio markedly increased (P<0.05). Multivariate Logistic regression analysis demonstrated that an increased TAPSE/PASP ratio and a decreased RMPI following PPV were independent predictors of 28-day all-cause mortality (P<0.05). Conclusion: PPV can immediately improve right heart function and RV-PA coupling in ARDS patients with shock. The TAPSE/PASP ratio monitored by TEE can serve as an important indicator for assessing the hemodynamic effects of PPV and predicting patient prognosis.
-
A Case of Schwannomatous Mucous Neuroma
Lu Ping; Gou Tao; Wang Yuanyuan; Zhao Jie
2026,41(4):506-507 ,DOI: 10.3969/j.issn.1005-3697.2026.04.020
Abstract:
<正>1 Case Report The patient is a 56-year-old male who presented with infiltrative red patches on the extensor surfaces of both lower legs accompanied by pruritus for 2 years. He had previously sought treatment at another hospital, where he received traditional Chinese medicine but showed poor efficacy. He was referred to our dermatology department on February 20, 2024. Physical examination revealed infiltrative red patches on the extensor surfaces of both lower legs. The lesions were intact without ulceration, hair growth, or local hypertrophy. They had well-defined borders from surrounding tissues, limited mobility, and a deep base without tenderness or blanching upon pressure. A biopsy was recommended. Laboratory tests, including complete blood count, biochemical panel, and preoperative infectious disease screening, showed no abnormalities. Macroscopic findings of the right lower extremity lesion: an irregularly shaped gray-brown tissue block with skin, measuring 1.7 cm × 0.7 cm × 0.8 cm. The tissue was excised along the skin surface, revealing a gray-white cut surface with medium consistency and myxoid texture.
-
Application of hospital-community-family linkage supervision model under the concept of behavioral goal attainment in elderly patients with stable COPD
Liu Yaohui; Liu Miao; Liu Jifeng; Li Cuiling
2026,41(4):508-512 ,DOI: 10.3969/j.issn.1005-3697.2026.04.021
Abstract:
Objective: To explore the application effect of implementing hospital-community-family linkage supervision model under the concept of behavioral goal attainment among elderly patients with stable chronic obstructive pulmonary disease (COPD). Methods: The clinical data of 107 elderly patients with stable COPD were collected. According to different nursing measures, the patients were divided into supervised group (n=54, hospital-community-family linkage supervision model under the concept of behavioral goal attainment) and control group (n=53, routine high-quality nursing). Both groups were nursed until the patients were discharged from hospital. The compliance behavior, pulmonary function, self-care ability and quality of life were compared between the two groups. Results: The scores of dimensions of COPD pulmonary rehabilitation training knowledge-attitude-practice questionnaire, pulmonary function level, scores of dimensions of exercise of self-care agency scale (ESCA) and score of COPD assessment test(CAT) in supervised group after intervention were higher than those in control group(P <0.05). Conclusion: Hospital-community-family linkage supervision model under the concept of behavioral goal attainment can effectively promote the compliance, improve the pulmonary function, enhance the self-care ability and improve the quality of life in elderly patients with stable COPD.
智能医学研究专题
Basic Medical Research
Clinical medical research
Short stories and cases
nursing
-
The manuscript processing system is used to test articles
Abstract:
Objective: To study the expression of miRNAs in peripheral blood of diabetic encephalopathy and to investigate the predicting effect of miRNA-368 on diabetic encephalopathy. Methods: qRT-PCR was used to detect the expression of miRNA-368 in peripheral blood of patients with diabetic encephalopathy in Sanya. MiRNA-368 was transfected into peripheral blood mononuclear cells of diabetic patients. The transfection efficiency was detected by qRT-PCR. The effect of miRNA-368 on the proliferation of peripheral blood mononuclear cells in diabetic brain patients was detected by CCK-8 and clonogenic assay. The effect of miRNA-368 on the peripheral blood mononuclear cell cycle and apoptotic rate in diabetic patients with cerebral encephalopathy was analyzed by flow cytometry. Results: The relative expression of miRNA-368 in 27 patients with diabetic encephalopathy was 1.402, and the 95% CI was 0.363-0.595. The relative expression level of miRNA-368 was not related to the general data of patients such as age and gender (P> 0.05), while the relative expression of miRNA-368 in patients with diabetic encephalopathy was significantly increased (P <0.05). The relative expression of miRNA-368 was significantly correlated with that of diabetic encephalopathy. QRT-PCR showed that peripheral blood of patients with diabetic encephalopathy and diabetic encephalopathy Monocyte miRNA-368 expression was significantly up-regulated. After the intervention of si-miRNA-368, the proliferation of peripheral blood mononuclear cells in diabetic brain patients was inhibited and the apoptosis rate increased. Conclusion: The expression of miRNA-368 in peripheral blood mononuclear cells of diabetic encephalopathy patients was significantly up-regulated, which promoted the development of diabetic encephalopathy.
其他
-
Development and validation of a malignancy risk prediction model for pul-monary nodules based on multivariable analysis and machine learning
Hu Xin; Jiang Yongjie; Shilun Guang; Heibieluo; Huang Yuyan; Jiang Li;
2025,40(6):686-692 712 ,DOI: 10.3969/j.issn.1005-3697.2025.06.002
Abstract:
Objective:To develop a robust and widely applicable predictive model to improve the accuracy of diagnosing the ma-lignancy risk of pulmonary nodules.Methods:This study retrospectively collected clinical data from 1,414 patients with pulmonary nod-ules diagnosed and treated at the Affiliated Hospital of North Sichuan Medical College and the Guang'an People's Hospital.Meta-analy-sis and Least Absolute Shrinkage and Selection Operator(LASSO)regression were used to identify predictors related to the malignancy risk of pulmonary nodules.These factors were further optimized by multivariable Logistic regression(LR)to determine key features.Based on these features,8 machine learning models were constructed and evaluated for performance using Receiver Operating Character-istic(ROC)curves,calibration curves,and Decision Curve Analysis(DCA)in the training set and internal validation set.The best-performing model was used to develop a nomogram for risk stratification of patients.Results:Through the combined screening process of Meta-analysis,LASSO regression,and multivariable LR,10 key predictive factors were identified and integrated into eight different ma-chine learning models.Model evaluation demonstrated that the LR model performed best,achieving an Area Under the Curve(AUC)of 0.843 in the internal validation cohort.Additionally,the nomogram derived from this model exhibited strong predictive ability in the ex-ternal validation cohort,with an AUC of 0.770.Risk scores calculated from the nomogram stratified patients into four risk groups,with malignancy rates ranging from 0%in the low-risk group to 100%in the very high-risk group.Conclusion:The prediction model devel-oped in this study effectively assesses the malignancy risk of pulmonary nodules,providing a valuable risk stratification tool for clinical use.
-
DOK1 recombinant adenovirus enhances insulin sensitivity of BRL-3A cells through DOK1/AKT/SREBP1c signalling pathway
Cai Xiaoling; Wang Chunlan; Ha Xiaoqin;
2025,40(6):681-685 ,DOI: 10.3969/j.issn.1005-3697.2025.06.001
Abstract:
Objective:To investigate the mechanism of DOK1 recombinant adenovirus(Ad-DOK1)on the regulation of insulin sensitivity in palmitic acid(PA)-induced insulin-resistant hepatocytes(BRL-3A).Methods:The control,solvent and model groups were treated with normal medium,ethanol and palmitic acid to establish a cellular insulin resistance model of BRL-3A cells and to iden-tify the cellular model using cellular glucose uptake assay.The control,null and adenovirus DOK1 overexpression groups were transfect-ed with normal serum,negative virus and Ad-DOK1(51257-1)in insulin-resistant BRL-3A cells,and the transfection efficiency of ade-novirus was detected by flow cytometry,and the Western blot method was used to detect DOK1,IRSI,IRSII,p-PI3K,PI3K,p-AKT,AKT,SREBP1c protein expression levels.Results:Palmitic acid induction for 6 hours resulted in a decrease in intracellular 2-deoxyglu-cose(P＜0.05),down-regulation of DOK1 protein expression level(P＜0.05),no significant change in IRSI and IRSII protein ex-pression level(P>0.05),no change in p-PI3K/PI3K ratio(P>0.05),down-regulation of p-AKT/AKT ratio(P＜0.05),and SREBP1c protein expression expression levels were upregulated(P＜0.05).After transfection of cells with DOK1 recombinant adeno-virus of optimal MOI 60,compared with the normal control group,intracellular 2-deoxyglucose was elevated(P＜0.05),DOK1 protein expression level was up-regulated(P＜0.05),there was no significant change in the expression level of IRSI and IRSII proteins(P>0.05),no significant change in the p-PI3K/PI3K ratio(P>0.05),the p-AKT/AKT ratio was upregulated(P＜0.05),and the ex-pression level of SREBP1c protein expression was downregulated(P＜0.05).Conclusion:Ad-DOK1 may enhance insulin sensitivity of BRL-3A cells by regulating AKT and SREBP1c.
-
Curative effect of Zixiandan combined with dipyridamole and its influences on levels of urine immunoglobulin G and β2 microglobulin in children with Henoch-Schonlein purpura
Zhang Lili; Shang Lili; Cui Heqing;
2025,40(5):573-576 ,DOI: 10.3969/j.issn.1005-3697.2025.05.006
Abstract:
Objective:To explore the curative effect of Zixiandan combined with dipyridamole and its influences on levels of u-rine immunoglobulin G and β2 microglobulin in children with Henoch-Schonlein purpura.Methods:According to different treatment methods,80 children with Henoch-Schonlein purpura were divided into control group(n=40,routine comprehensive treatment+dipy-ridamole)and observation group(n=40,Zixiandan on basis of control group),the course of treatment was 7～14 days.Clinical cura-tive effect,scores of TCM syndromes,recovery time of symptoms,renal function and adverse reactions were compared between the two groups.Results:The effective rate of treatment was higher in observation group than in control group(95.00%vs.72.50%,P<0.05).After treatment,scores of TCM syndromes were lower in observation group than control group(P<0.05),disappearance time of lbuminuria,remission time of purpura,length of hospital stay,disappearance time of joint symptoms and remission time of ab-dominal pain were shorter in observation group(P<0.05),levels of urine β2-MG and IgG were lower in observation group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion:Zixiandan combined with dipyridamole can improve TCM symptoms,reduce renal injury and promote recovery process in children with Henoch-Schonlein purpura,which has significant curative effect.
-
Clinical study of Nalbuphine as local anesthetic adjuvant for nerve block analgesia in elderly patients after total hip arthroplasty
Wang Huajuan; Liu Qiyu; Liu Jing; Li Mingming; Song Man; Li Fengjuan; Zheng Xiaozhen;
2025,40(10):1253-1258 ,DOI: 10.3969/j.issn.1005-3697.2025.10.007
Abstract:
Objective:To observe the effect of ultrasound-guided suprainguinal fascia iliaca compartment block(U-SFICB)with ropivacaine combined with different doses of nalbuphine on analgesia in elderly patients after total hip arthroplasty(THA).Methods:101 elderly patients with unilateral THA under general anesthesia were divided into four groups according to different anesthesia regimens:100 mg ropivacaine+normal saline group(R group,n=26),100 mg ropivacaine+10 mg nal-buphine group(LN group,n=25),and 100 mg ropivacaine+15 mg nalbuphine group(MN group,n=25),and 100 mg ropiv-acaine+20mg nalbuphine group(HN group,n=25),all were diluted to 30 mL with 0.9%sodium chloride injection.All four groups underwent U-SFICB in the post-anesthesia care unit(PACU),and sufentanil was used for patient-controlled intravenous analgesia after surgery.Comparison between groups of postoperative 4,8,12,24,and 48 h of resting and motion state of Numer-ical rating scale(NRS).Each group received 12 h preoperatively,12 and 24 h postoperatively,Interleukin 6(IL-6),Tumor nec-rosis factor-α(TNF-α),Interleukin 10(IL-10)concentration,the first start time of postoperative analgesia pump and 48 h of sufentanil use in each group,the early postoperative recovery of each group,and the occurrence of analgesia related adverse reac-tions 48 h after surgery were compared between groups.Results:Compared with R group and LN group,NRS score in MN and HN group was decreased at all time points(P<0.05),IL-6 and TNF-α concentrations were decreased at all time points(P<0.05),IL-10 concentrations were increased at all time points(P<0.05),and the start-up time of postoperative analgesia pump was significantly extended(P<0.05).The amount of sufentanil was significantly decreased 48 hours after operation(P<0.05).Compared with R group,LN group and HN group,the time of first anal exhaust and getting out of bed in MN group were significantly shortened(P<0.05).The incidence of adverse reactions was significantly decreased 48 h after operation(P<0.05).Compared with HN group,the start-up time of postoperative analgesic pump in MN group was significantly short-ened(P<0.05),and the overall incidence of adverse reactions was the lowest at 48 h after surgery(P<0.05).Conclusion:15 mg nalbuphine combined with ropivacaine can significantly prolong the duration of U-SFICB analgesia after THA in elderly pa-tients,and the first postoperative anal exhaust time and the first time of getting out of bed activity are the shortest,and the inci-dence of adverse reactions is the lowest within 48 hours after surgery,which can be clinically promoted and applied.
-
Effect of esketamine combined with erector spinae plane block on the qual-ity of recovery in patients after thoracoscopic lobectomy under general an-esthesia
Liu Tongxin; Hou Yongchao; He Peng; Zhang Zhenghui; Zhou Shuzhi;
2025,40(6):708-712 ,DOI: 10.3969/j.issn.1005-3697.2025.06.006
Abstract:
Objective:To investigate the effect of intravenous esketamine combined with erector spinae plane block(ESPB)on the postoperative recovery quality in patients undergoing thoracoscopic lobectomy with general anesthesia.Methods:A total of 97 pa-tients who underwent thoracoscopic lobectomy were divided into two groups:group K(n=49)and group C(n=48),according to whether or not they were given esketamine.Patients in K group were given slow intravenous injection of 0.2 mg/kg ketamine after anes-thesia induction and 5 minutes before surgical skin incision,and patients in group C received intravenous injection of physiological sa-line equivalent to group K drugs.Comparison of general indicators,quality of recovery at 24 h postoperatively[40-item Quality of Re-covery Rating Scale(QoR-40)score],cellular immune function before and after 24 h of treatment(NK cells,CD4+T cells,and CD8+T cells),hemodynamics at each time point,and the occurrence of postoperative adverse events between the two groups.Results:Intrao-perative remifentanil dosage was lower in group K than in group C(P＜0.05).The overall QoR-40 score,as well as the subscores for pain,emotional state,and physical comfort in group K were higher than those in group C at 24 hours postoperatively(P＜0.05).Addi-tionally,levels of NK cells,CD4+T cells,and CD8+T cells were higher in the group K than those in group C at 24 hours postoperative-ly(P＜0.05).There were no statistically significant differences in hemodynamics and total incidence of adverse effects between the two groups(P>0.05).Conclusion:The intravenous application of esketamine combined with ESPB for thoracoscopic lobectomy under general anesthesia reduces intraoperative remifentanil dosage,improves the quality of postoperative recovery and improves postoperative cellular immune function in patients without increasing adverse effects.
-
Correlation between serum brain-derived neurotrophic factor and mono-cyte to HDL-C ratio levels and post-stroke cognitive impairment in pa-tients with acute ischemic stroke
Shen Yongling; Fang Jianwei; Cheng Fei; Sang Xiaoyi; Meng Jun; Ma Cuihong; Gohong Country;
2025,40(5):624-627 ,DOI: 10.3969/j.issn.1005-3697.2025.05.018
Abstract:
Objective:To investigate the correlation between serum brain-derived neurotrophic factor(BDNF),monocyte to HDL-C ratio(MHR)and post-stroke cognitive impairment(PSCI)in patients with acute ischemic stroke(AIS).Methods:96 patients with acute AIS were collected and divided into PSCI group(n=39,<26 points)and non-PSCI group(n=57,≥26 points)accord-ing to the Montreal Cognitive Assessment(MoCA)score at 3 months after stroke.The clinical data such as serum BDNF and MHR lev-els at admission were statistically compared between the two groups,and the receiver operating characteristic(ROC)curve of BDNF and MHR levels in predicting PSCI was drawn.Results:Compared with the non-PSCI group,the PSCI group was older,had shorter years of education,had a higher proportion of hypertension,and had lower serum BDNF and higher MHR levels,the differences were signifi-cant(P<0.05).Logistic regression analysis showed that age(OR=1.530),hypertension(OR=1.335),serum BDNF level(OR=0.755)and MHR(OR=1.645)were risk factors for PSCI in AIS patients(P<0.05).ROC curve analysis showed that the AUC of BDNF and MHR levels in predicting PSCI were 0.833 and 0.745,respectively,and the AUC of the combined diagnosis of the two was 0.882,which was greater than that of a single index(P<0.05).Conclusion:Serum BDNF and MHR are closely related to PSCI in AIS patients.Both indicators can predict the occurrence of PSCI,and the combined detection of the two can improve the predictive abili-ty.
-
Effect and mechanism of miR-139-3p targeting SPP1 on cisplatin resist-ance in A549 lung cancer cells
2025,40(10):1225-1229 1248 ,DOI: 10.3969/j.issn.1005-3697.2025.10.001
Abstract:
Objective:To explore the effect and mechanism of miR-139-3p targeting secreted phosphoprotein 1(SPP1)on cis-diamminedichloroplatinum(DDP)in A549 lung cancer cells.Methods:A cisplatin(DDP)-resistant A549/DDP cell model was established via gradient concentration induction,validated by resistance index(IR=3.877)and IC50 determination.The re-sistant cells were divided into five groups:blank control,negative control,miR-139-3p mimic,SPP1 overexpression,and SPP1 knockdown.Multi-platform analyses were performed,including qPCR(miR-139-3p and SPP1 expression),Western blot(SPP1,p-AKT,and total AKT protein levels),CCK-8(proliferation and drug sensitivity),flow cytometry(apoptosis),and du-al-luciferase reporter assays(miR-139-3p/SPP1 interaction).Results:The cisplatin-resistant A549/DDP cells exhibited a signifi-cantly higher IC50 value compared to parental A549 cells(P<0.05),with a resistance index(IR)of 3.877.Quantitative PCR(qPCR)analysis revealed that miR-139-3p expression was markedly upregulated in the miR-139-3p mimic group versus the negative control group(P<0.05).Relative to the miR-139-3p mimic group,SPP1 mRNA levels were significantly elevated in the SPP1-overex-pression group and reduced in the SPP1-knockdown group(P<0.05).Western blotting confirmed corresponding changes in SPP1 pro-tein expression across these groups(P<0.05).CCK-8 assays demonstrated that miR-139-3p overexpression enhanced the proliferation inhibition rate and reduced the IC50 value compared to the negative control(P<0.05),whereas SPP1 overexpression reversed these effects,lowering the inhibition rate and increasing IC50(P<0.05).Compared with the miR-139-3p blank control,the luciferase activity of the wild-type SPP13'UTR luciferase reporter plasmid binding to miR-139-3p analog decreased(P<0.05),and the difference in the luciferase activity of the mutant SPP13'UTR luciferase reporter plasmid binding to miR-139-3p analog was not statistically significant(P>0.05).Compared with the negative control group,the protein expression level of p-AKT in miR-139-3p control group was signifi-cantly decreased(P<0.05),compared with the miR-139-3p control group and SPP1 knockdown group,the protein expression level of p-AKT in SPP1 overexpression group was significantly increased(P<0.05).Conclusion:Overexpression of miR-139-3p or knockdown of SPP1 could inhibit the proliferation of A549/DDP cells,enhance their sensitivity to cisplatin,and the mechanism may be related to the AKT signaling pathway.
-
Primary study of vortioxetine in inhibiting proliferation and migration of esophageal cancer cells
Roman; Ma Qiang; Zhong Xiaowu; Liao Zhongbo; Xu Lei; Guo Xiaolan;
2025,40(5):545-550 ,DOI: 10.3969/j.issn.1005-3697.2025.05.001
Abstract:
Objective:To investigate the effects and mechanisms of vortioxetine on the proliferation and migration of esophageal squamous cell cancer.Methods:CCK-8 assay was used to detect the viability of Eca109 and KYSE150 cells after treated with vortioxe-tine at different concentrations(0,2,4,6,8,10 μmol/L).Moreover,transwell and scratch assays were employed to evaluate the migra-tion of ESCC cells,plate colony formation assay was used to detect the proliferation.The differentially expressed genes were screened by TCGA database,AutoDock software was used to predict the binding of vortioxetine and cyclooxygenase-2(COX-2)protein.Further-more,the expression of COX-2 mRNA and protein were measured by RT-qPCR and Western blot,respectively.Results:The cell viabil-ity of Eca109 and KYSE150 decreased in a concentration-dependent manner after treatment with different concentrations of vortioxetine(P<0.05),and the semi-inhibitory concentrations(IC50)were 5.086 μmol/L and 5.179 μmol/L,respectively.Compared with the control group,the cell proliferation and migration of the vortioxetine group were reduced(P<0.05).In addition,vortioxetine could in-hibit the expression of COX-2 at mRNA and protein level(P<0.05).Conclusion:Vortioxetine inhibits the proliferation and migration of esophageal cancer cells probablly through COX-2 down-regulation.
-
Clinical effect of rigid neuroendoscopy and traditional drilling irrigation and drainage in treating chronic subdural hematoma
Dong Xichao; Wang Fenglu; Zhao Haikang; Rongbo;
2025,40(6):736-739 ,DOI: 10.3969/j.issn.1005-3697.2025.06.012
Abstract:
Objective:To explore the clinical effect of rigid neuroendoscopy and traditional drilling irrigation and drainage in the treatment of chronic subdural hematoma(CSDH).Methods:The clinical data of CSDH patients were retrospectively analyzed.Accord-ing to different treatment methods,they were divided into traditional group(treated with traditional drilling irrigation and drainage)and endoscopic group(treated with rigid neuroendoscopy),48 cases in each group.The differences in perioperative indicators,GCS score,Markwalder grading and NIHSS score were compared between groups,and the complications and recurrence rate in the two groups were counted.Results:The intraoperative blood loss,hospitalization time and immediate postoperative hematoma clearance rate in endoscopic group were better than those in traditional group(P＜0.05),and the total surgical time in traditional group was shorter than that in en-doscopic group(P＜0.05).At 7 days after surgery,the GCS score and Markwalder neurological function grading in the two groups were improved(P＜0.05),but there were no obvious differences between the two groups(P>0.05).Different time points after surgery,the NIHSS score in both groups was reduced compared to before surgery(P＜0.05),and the score was lower in endoscopic group than that in traditional group(P＜0.05).The complications showed no significant differences(P>0.05),and the recurrence rate of hematoma was lower than that in traditional group(P＜0.05).Conclusion:Both rigid neuroendoscopy and traditional drilling irrigation and drainage can effectively treat CSDH,but neuroendoscopy has higher hematoma clearance rate,shorter hospitalization time and lower postoperative recurrence rate,which is worthy of clinical promotion.
-
Effect of evolocumab in patients with early neurological deterioration after noncardiac acute ischemic stroke
Wang Xiaogan; Fan Ying; Fan Lijuan; Zhou Lifei; Gao Yongchao; Liu Minxiao;
2025,40(5):593-596 ,DOI: 10.3969/j.issn.1005-3697.2025.05.011
Abstract:
Objective:To examine the impact of the Evolocumab on early neurological deterioration(END)in patients with non-cardioembolic acute ischemic stroke(NCIS).Methods:A total of 110 patients diagnosed with NCIS and END were recruited as re-search subjects.All patients received standardized and systematic treatment protocols.Based on different therapeutic regimens,the pa-tients were categorized into two groups:the conventional group(n=55),which received standard dual antiplatelet therapy,and the ob-servation group(n=55),which received evolocumab in addition to the standard treatment regimen.The clinical efficacy,cerebral blood flow perfusion indicators[resistance index(RI),cerebral blood volume(CBV),and mean blood flow(Qmean)],levels of nerve func-tion reconstruction factors[nerve growth factor(NGF),gamma aminobutyric acid(GABA),and brain-derived neurotrophic factor(BDNF)],lipid metabolism indicators[apolipoprotein B(ApoB),low-density lipoprotein cholesterol(LDL-C)],and incidence of ad-verse reactions were compared between the two groups.Results:The total clinical efficacy rate in the observation group was higher than that in the conventional group(98.18%vs.85.45%,P<0.05).Post-treatment,the RI value in the observation group was lower than that in the conventional group(P<0.05).Additionally,post-treatment serum levels of CBV and Qmean,as well as NGF,GABA,and BDNF,were higher in the observation group compared to the conventional group(P<0.05).Conversely,post-treatment serum levels of Lp(a),ApoB,and LDL-C,and the total incidence of adverse reactions were lower in the observation group compared to the conventional group(P<0.05).Conclusion:Evolocumab enhances cerebral blood perfusion and facilitates neurological function recovery in NCIS patients with early END.Additionally,it regulates lipid metabolism and decreases the incidence of adverse reactions.
-
The causal relationship between sleep disorders and gastric ulcer incidence based on two-sample Mendelian randomization
2025,40(6):693-698 ,DOI: 10.3969/j.issn.1005-3697.2025.06.003
Abstract:
Objective:To investigate whether there was a potential two-way causal relationship between sleep disorder(SD)and the incidence of gastric ulcer(GU)by two sample Mendelian randomization(MR)analysis.Methods:The data sets of exposure and outcome were obtained from IEU database,from which suitable Single Nucleotide Poly Morphisms(SNPs)were selected as instrumental variables(IVs),and then inverse variance weighting(IVW),MR-Egger regression,weighted median(WME),simple model and weigh-ted model were used for two-way MR Analysis.Cochran's Q test and MR-Egger intercept test were used for sensitivity analysis.Results:The IVW method showed that there was a significant unidirectional causal relationship between SD and the incidence of GU.When SD were used as exposure factors,the positive MR Analysis had significant statistical significance(OR=1.009,95%CI:1.004～1.015,P=0.001).When GU used as an exposure factor,reverse MR Analysis was not statistically s-ignificant(OR=1.197,95%CI:0.425～3.371,P=0.734).Further sensitivity analysis showed no significant heterogeneity and horizontal pleiotropy.Conclusion:Mendelian randomization analysis found that there is a potential one-way causal relationship between SD and the risk of GU,and SD are risk factors for GU.
-
Relevant studies that NETs promote the secretion of inflammatory media-tors by alveolar-type epithelial cells
Xu Suqing; Tian Jiamei; Lu Hongyan;
2025,40(5):557-561 ,DOI: 10.3969/j.issn.1005-3697.2025.05.003
Abstract:
Objective:To explore the role of neutrophil extracellular traps(NETs)in promoting the secretion of inflammatory mediators by alveolar type epithelial cells(AECII).Methods:In 30 7 d born SD rats,blood was drawn from neutrophils(NE)and di-vided into control(control group),LPS and LPS+DNase groups according to different treatment methods.NETs formation was detec-ted by immunofluorescence in vitro.NETs and AECII were co-cultured,and divided into control group(control group),NETs group and NETs+DNase group according to cell suspension incubation method.AECII apoptosis was detected by flow method,the content of free deoxyribonucleic acid(cf-DNA)in coculture supernatants in each group was detected by fluorescence microarray,and the coculture su-pernatants of interleukin 6(IL-6),interleukin 8(IL-8)and tumor necrosis factor(TNF-α)in each group were determined using ELISA kit.And,the correlation between cf-DNA and IL-6,IL-8,and TNF-α was evaluated using Pearson correlation analysis.Results:According to immunofluorescence,mouse citrullinated histone H3(CitH3)and myeloperoxidase(MPO)were found in neutrophil in LPS and LPS+DNase group,CitH3 and MPO levels in LPS and LPS+DNase groups were higher than in the control group(P<0.05),and CitH3 and MPO in LPS+DNase group were lower than those in LPS group(P<0.05).After AECII apoptosis with NE and NETs,there was no significant difference between early and late apoptosis in the three groups(P＞0.05).The levels of cf-DNA,IL-6,IL-8,and TNF-α in NETs group and NETs+DNase group were higher than those of the control group(P<0.05),NETs+DNase group was lower than NETs group(P<0.05).The content of cf-DNA in cell culture supernatant was positively correlated with the levels of IL-6,IL-8,and TNF-α(r=0.432,0.387,0.326,P<0.05).Conclusion:AECII with NETs in the supernatants with NE,NETs could promote the secretion of inflammatory mediators such as IL-6,IL-8,and TNF-α.Moreover,the more NETs are generated,the more inflammatory mediators such as IL-6,IL-8,and TNF-α are secreted.
-
Analysis of prognostic factors in patients with septic cardiomyopathy and development of prediction model
Li Pengfei; Lin Jiafu; Yuan Shun; Jiang Zhi;
2025,40(6):764-769 ,DOI: 10.3969/j.issn.1005-3697.2025.06.018
Abstract:
Objective:To investigate the predictive factors of prognosis in patients with septic cardiomyopathy and building pre-diction model.Methods:A retrospective study was conducted on 156 patients with purulent pericarditis,and they were divided into a model set and a validation set in a 7∶3 ratio.The patients in the model set were divided into survival and death groups according to dif-ferent outcomes.The influence factors on the prognosis of the model set patients were evaluated by multivariate Cox regression analysis,and a ROC curve and decision curve analysis(DCA)were used to validate the model using R software.Results:Multiple COX regres-sion analysis indicated that lactic acid,D-dimer,interleukin-6,APACHE-Ⅱscore and SOFA score were independent risk factors for 28 deaths in hospital with septic cardiomyopathy.ROC curve analysis results showed that the predictive value curve area(AUC)of the model set was 0.90,and the AUC of the validation set was 0.83,indicated that the model has good value in the prognosis of patients with septic cardiomyopathy.The results of the clinical decision curve(DCA curve)suggested that the clinical benefit of the validation set and the model set in this model was superior to the"assume all patients die"(all)and"assume all patients die"(none)curves.Conclusion:The prediction model has a good fit to the actual and correction curves,approaching the ideal curve,and has certain clini-cal practical value for patients with septic cardiomyopathy.
-
Application value of contrast-enhanced CT histogram parameters in mor-tality risk assessment of severe acute pancreatitis
Taodi; Zhao Zisheng; Chen Junhui; Zhang Xiaoming;
2025,40(5):562-568 ,DOI: 10.3969/j.issn.1005-3697.2025.05.004
Abstract:
Objective:To optimize contrast-enhanced computed tomography(CECT)image quality using Non-Local Means(NLM)denoising technology and construct a mortality risk prediction model for severe acute pancreatitis(SAP)patients based on his-togram parameters.Methods:Retrospective analysis of clinical,laboratory,and CECT data of 74 patients diagnosed with SAP.NLM de-noising was applied to arterial and portal venous phase images at different coefficient levels.Three-dimensional volumes of interest were manually delineated in pancreatic parenchyma on original and denoised images,followed by histogram parameter extraction.After univa-riate Logistic regression feature selection,binary Logistic regression models were built to predict SAP mortality risk and compared with clinical models and conventional CT models.Results:A total of 74 patients with SAP,of whom 27(36.5%)died.After applying NLM-based noise reduction to arterial phase and portal venous phase CECT images,8 histogram prediction models were constructed under dif-ferent noise coefficient levels.There was no significant difference in predictive performance among these histogram models(P＞0.05).Compared to conventional CT models and clinical models,the histogram models demonstrated higher accuracy in predicting mortality risk(P=0.009,P=0.048).The predictive performance of the clinical model and the conventional CT model was similar(P=0.699).Conclusion:CECT histogram parameters show significant clinical value in predicting mortality risk in SAP patients,maintaining stable performance under different noise coefficient levels after NLM denoising.Their noise robustness and quantitative a-nalysis advantages compensate for the limitations of conventional CT.
-
Value of lung ultrasound score combined with peripheral blood procalci-tonin,C-reactive protein and interleukin-6 levels on evaluating the disease severity and prognosis of patients with acute respiratory distress syn-drome
Wang Xiyu; Liao Rui; Wang Zhong;
2025,40(10):1244-1248 ,DOI: 10.3969/j.issn.1005-3697.2025.10.005
Abstract:
Objective:To explore the value of lung ultrasound(LUS)score combined with peripheral blood procalcitonin(PCT),C-reactive protein(CRP)and interleukin-6(IL-6)levels on evaluation of disease severity and prognosis of patients with acute respiratory distress syndrome(ARDS).Methods:109 patients with ARDS were selected.The disease severity and progno-sis of patients were grouped according to the Berlin criteria for ARDS.The baseline data were compared among mild group(n=24),moderate group(n=55)and severe group(n=30).According to the prognosis,they were divided into a survival group(n=68)and a death group(n=41).The differences in LUS score,peripheral blood PCT,CRP and IL-6 levels among the three groups and patients with different prognoses were analyzed,and the evaluation value of the above indexes on the disease severity and prognosis was analyzed.Results:There were statistical differences in prognosis and APACHE Ⅱ score among the three groups(P<0.05).The survival rate of patients in severe group was lower than that in moderate group(P<0.05),and the rate in moderate group was lower than that in mild group(P<0.05).The APACHE Ⅱ score of patients in severe group was higher than that in moderate group(P<0.05),and the score in moderate group was higher than that in mild group(P<0.05).The LUS score and peripheral blood PCT,CRP and IL-6 levels revealed statistical differences among ARDS patients with different disease severities(P<0.05).The severe group was higher than the moderate group(P<0.05),and the moder-ate group was higher than the mild group(P<0.05).Spearman analysis showed that LUS score and peripheral blood PCT,CRP and IL-6 in ARDS patients were positively correlated with disease severity(P<0.05).The LUS score,PCT,CRP and IL-6 in death group were higher than those in survival group(P<0.05).After Logistic regression analysis,it was found that A-PACHE Ⅱ score,LUS score,PCT,CRP,IL-6 and disease severity were the influencing factors of prognosis in patients with ARDS(P<0.05).ROC curve results showed that the areas under the ROC curves of LUS score,peripheral blood PCT,CRP and IL-6 and combined detection for predicting the death prognosis in ARDS patients were 0.778,0.781,0.864,0.856 and 0.982,and the sensitivities were 75.61％,78.05％,90.24％,80.49％and 92.68％,respectively.The combined detection value was higher.Conclusion:LUS score and peripheral blood PCT,CRP and IL-6 levels can effectively evaluate the disease severity of ARDS patients,and have reliable predictive value for prognosis of patients.
-
Distribution of peripheral blood B cell subsets in patients with systemic lupus erythematosus and their clinical applications
2025,40(10):1285-1290 ,DOI: 10.3969/j.issn.1005-3697.2025.10.014
Abstract:
Objective:To analyze the distribution of peripheral blood B cell subsets in patients with systemic lupus erythe-matosus(SLE)and their clinical applications.Methods:52 SLE patients(SLE group),36 healthy controls(HC group)and 30 rheumatoid arthritis(RA group)patients were included.The percentage of B1,FOB,Breg and ABC cells in total B cells was measured by Flow cytometry.Diagnostic efficacy of individual and combined B cell subsets for SLE was evaluated via ROC curves.Clinical data on SLE activity score(SLEDAI),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),com-plement C3 and C4,immunoglobulin,and various autoantibodies from SLE patients were collected,and the correlations between the subsets percentage and these indicators were analyzed.Results:Compared to HC group,the percentage of B1,Breg,and ABC were higher in SLE group(P<0.05)and the percentage of FOB was lower(P<0.05).The percentage of B1,and Breg in SLE group were obviosly higher than those in RA group(P<0.05)and FOB was lower(P<0.05).There was no statistically sig-nificant difference in the proportion of cells in each subgroup between the RA group and the HC group(P>0.05).ROC curve analysis showed that all B cell subgroups had a certain diagnostic efficacy for SLE,and the combination of multiple subgroups had a higher diagnostic efficacy for SLE.The area under the curve(AUC)of 11 combinations for diagnosing SLE was 0.756～0.892(P<0.05),with(ABC+B1+Breg+FOB)combined was highest.Results of Assay of correlations showed that the per-centage of ABC cells positively correlated with the level of ESR(P<0.05,r=0.403).The percentage of Breg cells negatively correlated with the level of C3(P<0.05,r=-0.421)and positively correlated with the level of anti-dsDNA(P<0.05,r=0.488),anti-M2(P<0.05,r=0.604),SLEDAI(P<0.05,r=0.353).ABC and FOB were negatively correlated in the SLE group(P<0.05,r=-0.571),while there was no correlation between the two in the HC and RA groups(P>0.05).Conclu-sion:There are differences in the distribution of B cell subsets between SLE patients and the normal population.The combina-tion of single or multiple indicators has good diagnostic efficacy for SLE,and the distribution of subsets is correlated with multi-ple clinical and laboratory indicators,suggesting that it may have value in disease diagnosis and disease assessment.
-
Effects of iTBS and 1 Hz rTMS on depressive symptoms and cognitive function in elderly patients with depression
Zhou Xueying; Xu Deyi; Shang Fangjie;
2025,40(6):703-707 ,DOI: 10.3969/j.issn.1005-3697.2025.06.005
Abstract:
Objective:To explore the effects of intermittent theta burst magnetic stimulation(iTBS)and 1 Hz repetitive tran-scranial magnetic stimulation(rTMS)on depressive symptoms and cognitive function in elderly patients with depression.Methods:Eld-erly patients with depression were divided into iTBS group(n=30)and 1 Hz rTMS group(n=43)according to the treatment regi-men.On the basis of antidepressant treatment for both groups,the left dorsolateral prefrontal lobe of the iTBS group was given a stimula-tion frequency of 50 Hz from the internal frequency,5 Hz from the inter-frequency and stimulation strength of 110%RMT,with a stimu-lation time of 2 s,an intermission of 8 s,and a repetition of 20 times,with a total of 600 pulses lasting for 200 s.The 1 Hz rTMS group was given a stimulation frequency of 1.0 Hz and a stimulation intensity of 110%RMT in the dorsolateral right prefrontal lobe,and was treated for 20 min per day,with a total of 1,200 pulses per treatment.Patients in both groups were treated 5 times per week at the same fixed time for 4 weeks for a total of 20 treatments.The Hamilton Depression Scale 24(HAMD-24),Geriatric Depression Scale(GDS),Beck Suicidal Ideation Inventory-Chinese Version(BSI-CV),Wisconsin Card Sorting Test,and Part A of the Connection Test were used for assessment before and after treatment,and adverse reactions during treatment were recorded.Results:With the prolongation of treat-ment time,the HAMD-24 and GDS scores of the two groups gradually decreased(P＜0.05),and the HAMD-24 and GDS scores of the iTBS group were lower than those of the 1 Hz rTMS group,and the difference was statistically significant(P＜0.05).After4 weeks of treatment,the number of correct responses of the patients in the iTBS group was higher than that of the 1 Hz rTMS group,and the num-ber of incorrect responses,BSI-CV score suicidal ideation intensity and suicide risk were lower than those of the 1 Hz rTMS group,and the TMT-A time was shorter than that of the 1 Hz rTMS group,with a statistically significant difference between the groups(P＜0.05).During the treatment period,there was no statistically significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion:There are significant advantages of iTBS over1 Hz rTMS in treating elderly patients with depression in terms of improving depressive symptoms,reducing suicidal ideation,and improving cognitive performance,and there was no increased treatment safety risk.
-
Influence of placental morphology and pathological changes on neonatal outcome in patients with premature rupture of membranes
Gold mineralization; Zhong Hui; Long Luwen; Zhong Wenna;
2025,40(6):787-790 ,DOI: 10.3969/j.issn.1005-3697.2025.06.023
Abstract:
Objective:To study the influence of placental morphology and pathological changes on neonatal outcome in patients with premature rupture of membranes(PROM).Methods:100 parturients with PROM were selected as the study group,and 100 nor-mal parturients without PROM during the same period were selected as the control group.HE staining was used to observe the Placental pathological changes and monitor pregnancy outcome.The Placental pathological changes and pregnancy outcome were compared be-tween the two groups.The influencing factors of premature rupture of membranes were analyzed by Single factor and multiple factor Lo-gistic regression analysis.Results:The incidence of placental pathological changes in the study group was higher(P＜0.05).The inci-dence of adverse pregnancy outcome in the study group was higher than that in the control group(23.00%vs.5.00%,P＜0.05).Uni-variate analysis showed that there were no statistically significant difference in the incidence of uterine malformations,cervical dysfunc-tion,polyhydramnios,anemia during pregnancy,placenta previa,and history of induced labor or miscarriage between the two groups(P>0.05).In the study group,gestational diabetes,hypertension,abnormal fetal position,multiple births,reproductive tract infection and unknown causes were all higher(P＜0.05).Logistic regression analysis showed that the abnormal fetal position,multiple births,and reproductive tract infection were all independent risk factors for premature rupture of membranes(P＜0.05).Conclusion:Prema-ture rupture of membranes is affected by abnormal fetal position,multiple pregnancies,and reproductive tract infections,and the placenta of patients with premature rupture of membranes has pathological changes,which will lead to poor neonatal outcome.
-
Efficacy of recombinant human interferon α-1b combined with budesonide aerosol inhalation in treating acute bronchitis in children
Wei Qiong; Rao Rui; Xu Wenyi; Yang Luling; Lu Zhili; Li Zhixin;
2025,40(6):774-777 ,DOI: 10.3969/j.issn.1005-3697.2025.06.020
Abstract:
Objective:To explore the clinical efficacy of recombinant human interferon α-1b combined with budesonide and sin-gle budesonide aerosol inhalation in the treatment of acute bronchitis in children.Methods:106 children with acute bronchitis were se-lected as study samples,and were divided into control group and study group by adopting different treatment methods,with 53 cases in each group.The children in the control group were treated with budesonide aerosol inhalation inhalation in addition to conventional treatment,while the children in the study group were combined with budesonide and recombinant human interferon α-1b aerosol inhala-tion inhalation on the basis of conventional treatment,both groups were treated for 1 week.The regression times of clinical symptoms,changes in serum inflammatory factors levels[procalcitonin(PCT),serum C-reactive protein(CRP)],blood routine[white blood cell count(WBC),neutrophil percentage(NEU%)]and lung function indexes[maximum expiratory volume in one second(FEV1),FEV1 to forced vital capacity ratio(FEV1/FVC),and maximum expiratory flow(PEF)]before treatment and after 1 week of treatment and adverse reactions during treatment were compared.Results:The regression times of clinical symptoms in study group were shorter than those in control group(P＜0.05).After 1 week of treatment,the levels of serum PCT,CRP,WBC and NEU%were lower in study group than those in control group(P＜0.05).The FEV1/FVC,PEF and FEV1 in study group were higher compared with those in con-trol group(P＜0.05).During treatment,there were no statistical differences in the incidence rates of adverse reactions between both groups(P>0.05).Conclusion:Recombinant human interferon α-1b combined with budesonide aerosol inhalation inhalation for chil-dren with acute bronchitis can quickly relieve the clinical symptoms,and improve the inflammation level,and it has high safety.
-
Diagnostic value of multimodal magnetic resonance imaging in grading and Subtype of meningiomas
Ji Xiaoxiao; Lv Hairong; Jia Rongrong; Zhao Feng;
2025,40(6):713-718 ,DOI: 10.3969/j.issn.1005-3697.2025.06.007
Abstract:
Objective:To analyze the diagnostic value of multimodal magnetic resonance imaging(MRI)in grading and Sub-type of meningiomas.Methods:A total of 98 patients with meningiomas were reviewed.They were divided into benign group(n=78)and malignant group(n=20)according to the pathological examination results.All of them underwent conventional MRI scan and mul-timodal MRI examination upon admission.The multimodal MRI parameters[apparent diffusion coefficient(ADC),local cerebral blood flow(rCBF),magnetic sensitive signal intensity(ITSS),N-acetylaspartate(NAA)/choline(Cho),NAA/creatine(Cr),Cho/Cr]of patients with benign and malignant meningiomas,and patients with different subtypes of benign meningiomas were compared.The diag-nostic value of multimodal MRI for meningioma classification and grading were analyzed by receiver operating characteristic(ROC)curves.Results:The ADC,NAA/Cho ratio and NAA/Cr ratio of meningiomas in the malignant group were lower than those in the be-nign group(P＜0.05).The rCBF,ITSS and Cho/Cr ratio were higher than those in the benign group(P＜0.05).The AUC values of three-dimensional arterial spin labeling(3D-ASL),diffusion-weighted imaging(DWI),susceptibility-weighted imaging(SWI)and proton magnetic resonance spectroscopy(1 H-MRS)for grading of meningiomas were 0.723,0.735,0.777 and 0.870.The AUC of com-bined diagnosis was 0.957.There were significant differences in rCBF,ITSS,NAA/Cho ratio,NAA/Cr ratio and Cho/Cr ratio among patients with different subtypes of benign meningiomas(P＜0.05).Conclusion:Multimodal MRI is helpful in clinical grading and Subtype of meningiomas.
Basic Medical Research
Clinical medical research
Basic Medical Research
Clinical medical research
Basic Medical Research
Clinical medical research
Editor in chief：Dai Rongyang
Deputy Editor-in-Chief：Li Zhi，Zhang Xiaoming
Organizer：Sichuan Provincial Department of Education
GoverningBody：North Sichuan Medical College
Phone：0817-2242637
Email：xuebaocby@126.com
ISSN1005-3697
CN51-1254/R
news- Our school's journal has been awarded the certificate of "OA Open Access Model Journal"
- Good news - Our university's journal has reached a new high in the Q1 ranking of national comprehensive medical and health journals
- Instructions for using the author's uploaded unit introduction letter
- The Qinyun remote manuscript processing system for the Journal of North Sichuan Medical College has officially been launched!!!
External Links