Objective: To investigate the current status of knowledge, attitude and practice (KAP) regarding prosthetic dislocation prevention among patients after total hip arthroplasty (THA), and to analyze the correlations among KAP dimensions and their influencing factors, so as to provide evidence for stratified health education and continuous rehabilitation management. Methods: By convenience sampling, 302 postoperative THA patients from the orthopedic outpatient and inpatient departments of two tertiary Grade A hospitals in Nanchong from June to September 2022 were surveyed face to face using a self-developed KAP questionnaire for prosthetic dislocation prevention. Descriptive statistics, t-test, one-way analysis of variance, Pearson correlation analysis and multiple linear regression were used. Results: The scores of knowledge, attitude and practice were 47.78±15.43, 51.37±9.94 and 30.56±7.98, respectively, with scoring rates of 63.70%, 85.62% and 61.13%. Pearson correlation analysis showed positive correlations between knowledge and attitude, knowledge and practice, and attitude and practice (r=0.471, 0.829 and 0.435, all P<0.001). Multiple linear regression showed that age, marital status, educational level, employment status, occupation, primary THA status and rehabilitation complications were influencing factors for knowledge scores; employment status, occupation and rehabilitation complications were influencing factors for attitude scores; age, employment status, occupation, time since primary THA and rehabilitation complications were influencing factors for practice scores (all P<0.05). Conclusion: The overall KAP level regarding prosthetic dislocation prevention among postoperative THA patients needs further improvement. Attitude is relatively positive, whereas knowledge and practice remain insufficient. Clinical nurses should focus on older adults, patients with lower educational levels, unemployed patients, primary THA recipients and patients without complication-related warning experiences, while also assessing patients with limited economic resources. Stratified, continuous and visual health education and follow-up management should be implemented to promote standardized preventive behaviors.