Objective:To investigate the efficacy and safety of calcium,niergoline combined with flunarizine in the treatment of peripheral vestibular vertigo.Methods:A total of 106 patients with peripheral vestibular vertigo were selected.They were divided into group A(Flunarizine,n=36),group B(Nyergoline+Flunarizine,n=35)and group C(calcium+Nyergoline+Flunarizine,n=35)according to different intervention methods,all groups were treated for 6 weeks.The degree of dizziness[dizziness handicap inven-tory(DHI)],dizziness symptoms[vertigo symptom scale-short form(VSS-SF),vestibular symptom index(VSI)scores],hemodynam-ic parameters[whole blood viscosity,hematocrit,vertebral artery mean velocity(Vm),basilar artery Vm],treatment effect,adverse re-actions during treatment and recurrence 6 months after treatment were compared among the groups before and after treatment.Results:After treatment,DHI scores,VSS-SF scores and VSI scores of physical,functional and emotional dimensions in group B and group C were lower than those in group A(P＜0.05).After treatment,the clinical effective rate of group B and group C was higher than that of group A(P＜0.05).After treatment,the whole blood viscosity and hematocrit of groups B and C were lower than those of group A(P＜0.05),and the Vm of vertebral artery and basilar artery were higher than those of group A(P＜0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P＞0.05).The recurrence rate of the three groups 6 months after treatment was significantly different(27.78％vs.25.71％vs.5.71％,P＜0.05).Conclusion:Calcium,niergoline combined with flunarizine is effective in the treatment of peripheral vestibular vertigo,and is beneficial to reduce the risk of disease recurrence.