Objective:To investigate the effect of dapagliflozin combined with recombinant human brain natriuretic peptide(rh-BNP)in patients with acute heart failure(AHF)and its effects on serum related factors.Methods:104 patients with AHF were divided into control group and observation group according to different treatment methods,52 cases in each group.The control group was treated with rhBNP,and the observation group was treated with dapagliflozin combined with rhBNP.The curative effect was evaluated after 7 days of treatment.The left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),Kansas Cardiomyop-athy Questionnaire(KCCQ)score,serum N-terminal pro-brain natriuretic peptide(NT-proBNP),cardiac troponin(cTnT),high-sensi-tivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)levels were compared between the two groups.The hospitalization time,in-hospital mortality,30-day readmission rate and adverse reactions of the two groups were statistically analyzed.Results:After treatment,the total effective rate of treatment of the observation group was higher than that of the control group(P＜0.05).Compared with the control group,the observation group had higher LVEF level,KCCQ score and lower LVEDD(P＜0.05),and the serum levels of NT-proBNP,cTnT,hs-CRP and IL-6 in the observation group were lower(P＜0.05).Compared with the control group,the hospitalization time of the observation group was shorter(P＜0.05),there was no significant difference in the incidence of in-hospital death,30-day readmission rate and adverse reactions between the two groups(P＞0.05).Conclusion:Dapagliflozin combined with rhBNP in patients with AHF can reduce inflammation,down-regulate serum NT-proBNP and cTnT levels,improve cardiac function,improve efficacy,and have good safety.