Objective:To investigate the effects of comprehensive nursing based on NRS2002 nutritional assessment on asthenia,nutritional status and ability of daily living in elderly patients with chronic heart failure combined with frailty.Methods:204 elderly pa-tients with chronic heart failure combined with frailty were included and divided into observation group and control group according to different intervention methods,with 102 cases in each group.The control group took routine nursing program,and the observation group took comprehensive nursing program based on NRS2002 nutritional assessment.The intervention time was 6 months,frailty,nutritional status,ability of daily living before and after intervention length of stay and readmission rate were compared between the two groups.Re-sults:After 6 months of intervention,the scores and total scores of somatic,psychological,and social frailty dimensions in Tilburg frailty indicator(TFI)of patients in the observation group was lower than the control group(P＜0.05).The serum albumin(Alb),prealbu-min(PA),transferrin(TF)and hemoglobin(Hb)levels in the observation group were higher than those in the control group(P＜0.05).The scores of the activity of daily living(ADL)in the observation group was higher than that in the control group(P＜0.05).The length of hospital stay in the observation group was shorter than that in the control group(P＜0.05),and the readmission rate dur-ing follow-up was lower than that in the control group(P＜0.05).Conclusion:Comprehensive nursing based on NRS2002 nutritional assessment can improve the frailty degree and nutritional status of elderly patients with chronic heart failure and frailty,improve their daily living ability,shorten the rehabilitation process,and reduce the risk of readmission.