Objective:To explore the efficacy of acupuncture combined with tamsulosin in the treatment of type Ⅲ prostatitis and its effect on inflammatory response and hemorheology.Methods:92 patients with type Ⅲ prostatitis were divided into control group(n=46)and observation group(n=46)according to different treatment methods.The control group was given tamsulosin,the observa-tion group was given acupuncture combined with tamsulosin,they were both treated continuously for 8 weeks.The clinical efficacy,symptoms of prostatitis[National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI)score],levels of inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],and hemorheological indicators[whole blood high shear viscosity(HBV),whole blood low shear viscosity(LBV),whole blood reduced viscosity(RV)]before and after treatment were compared be-tween the two groups.Results:The total effective rate of observation group was higher than that of control group(86.96％vs.65.22％,P＜0.05).After 8 weeks of treatment,the NIH-CPS score and the levels of IL-6,TNF-α,HBV,LBV and RV in both groups showed a decrease,and the observation group was lower than the control group(P＜0.05).Conclusion:Acupuncture on the basis of tamsulosin in the treatment of type Ⅲ prostatitis can improve the clinical efficacy,relieve related symptoms,inhibit inflammatory response and im-prove hemorheology.