Objective:To explore the effects of Hemabate and oxytocin separately combined with bilateral ligation of the ascend-ing branches of the uterine artery in preventing uterine atony-related postpartum hemorrhage(PPH),and the impact on patients'hemo-dynamics,fibrinogen(FIB)and D-dimer(D-D).Methods:According to the treatment methods,70 patients with uterine atony during cesarean section were grouped.Among them,35 patients treated with oxytocin combined with bilateral ligation of the ascending branches of the uterine artery were included in the control group,while 35 patients treated with Hemabate combined with bilateral ligation of the as-cending branches of the uterine artery were included in the observation group.The intraoperative and postpartum bleeding,postoperative maternal-infant outcomes,hemodynamics,D-D and FIB before and after treatment,clinical efficacy,and the incidence of adverse reactions were compared between the two groups.Results:Operation time,time to off-bed activities,lochia disappearance time,and length of hospital stay in the observation group were shorter than those in the control group.The intraoperative blood loss,2 h postoperative blood loss and 3～24 h postoperative blood loss of the observation group were less than those of the control group(P＜0.05).The blood transfusion rate in the observation group was lower than that in the control group(5.71％vs.22.86％,P=0.040).There was no significant difference in hysterectomy rate,neonatal Apgar score,heart rate(HR),and mean arterial pressure(MAP)between the two groups(P＞0.05).Af-ter treatment,the levels of D-D and FIB in both groups decreased(P＜0.05),and the observation group was lower than the control group(P＜0.05).The total effective rate of the observation group(94.29％)was higher than that of the control group(77.14％)(P=0.040).During the treatment period,there was no statistically significant difference in the incidence of adverse reactions such as abnor-mal blood pressure and nausea and vomiting between the two groups(P＞0.05).Conclusion:Hemabate combined with bilateral liga-tion of the ascending branches of the uterine artery is effective in preventing uterine atony-related PPH.It can reduce blood loss,lower blood transfusion rate,improve D-D and FIB levels,promote postpartum recovery,and shorten hospital stay,with high safety.