Objective:To explore the relationship between eradication therapy of different virulence types of Helicobacter pylori(Hp)and kidney injury.Methods:130 patients undergoing Hp eradication therapy were selected as the research subjects,and 50 healthy individuals who underwent physical examinations during the same period were selected as controls.The levels of urinary specific proteins[neutrophil gelatinase-associated lipocalin(NGAL),retinol binding protein(RBP),microalbumin/creatinine(MALB/CREA)]were compared between the two groups.Patients were divided into kidney injury group(n=29)and non kidney injury group(n=101)based on whether kidney injury occurred.The levels of urinary specific proteins(NGAL,RBP,MALB/CREA)in the two groups were compared,and the diagnostic value of urinary specific proteins for kidney injury was analyzed using receiver operating char-acteristic curve(ROC).Detected Hp virulence genes in all patients and analyzed the relationship between different Hp virulence genes and kidney injury.Results:The levels of NGAL,RBP,and MALB/CREA in the study group were higher than those in the control group(P＜0.05).The levels of NGAL,RBP,and MALB/CREA in the kidney injury group were higher than those in the non kidney injury group,and their levels had good diagnostic efficacy for Hp eradication treatment patients with kidney injury.The combination of the three had the highest diagnostic efficacy,with an AUC of 0.764,sensitivity of 82.76％,and specificity of 66.34％.The positive expres-sion rates of CagA,Vac A,Ure,and CagA+Vac A in Hp eradication treatment patients were higher than those in healthy individuals(P＜0.05),but there was no significant difference in the positive expression rates of CagA,Vac A,Ure,and CagA+Vac A between the kidney injury group and the non kidney injury group(P＞0.05).Conclusion;NGAL,RBP,and MALB/CREA are highly expressed in patients undergoing Hp eradication therapy,and their expression levels have a certain predictive power for renal injury in patients.How-ever,there is no significant correlation between Hp virulence typing and renal injury in patients.