Objective:To explore the predictive value of combined detection of peripheral blood chemokine ligand-18(CCL18),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and high-sensitivity C-reactive protein/albumin(hs-CRP/Alb)on the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:The data of 286 pa-tients with AECOPD were retrospectively analyzed and the patients were enrolled as study group,they were classified into grade Ⅰ(n=91),Ⅱ(n=122),and Ⅲ(n=73)groups by disease severity,and divided into poor prognosis group(n=63)and good prognosis group(n=223)according to the prognosis,and 200 healthy subjects with physical examination were selected as control group.The lev-els of CCL18,sTREM-1 and hs-CRP/Alb in peripheral blood were compared between the two groups.The levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb were compared among patients with different disease severities.To analyze the correlation between levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb and disease condition.To analyze the predictive value of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb levels on the prognosis of AECOPD patients.Results:The levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb in study group were higher than those in control group(P＜0.05).The levels of CCL18,sTREM-1 and hs-CRP/Alb in peripheral blood of patients with AECOPD grade Ⅰ were lower than those of patients with grade Ⅱ or Ⅲ AECOPD(P＜0.05),and the above levels of patients with AECOPD grade Ⅱ were lower than those of patients with AECOPD grade Ⅲ patients(P＜0.05).The levels of CCL18,sTREM-1 and hs-CRP/Alb in peripheral blood were higher in poor prognosis group than those in good prognosis group(P＜0.05).Spearman correlation coefficient analysis showed that the levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb were positively correlated with disease condition of AECOPD patients(P＜0.05).Receiver operating characteristic curve curve analysis suggested that the sensitivities of CCL18,sTREM-1,hs-CRP/Alb alone and in combination in predicting the prog-nosis of AECOPD patients were 71.43％,71.43％,76.19％and 84.13％respectively,and the specificities were 70.40％,72.20％,73.99％and 68.16％,and the AUCs were 0.791,0.777,0.821 and 0.935 respectively.The combined diagnostic value was higher(P＜0.05).Conclusion:The levels of serum CCL18,sTREM-1 and hs-CRP/Alb in patients with AECOPD are up-regulated,and are correlated with disease condition,and they can be used for prognosis evaluation.