Objective:To analyze the clinical efficacy of early application of Buyang Huanwu Decoction after Zero-P interverte-bral fusion fixation surgery in the treatment of cervical spondylotic radiculopathy.Methods:90 patients with cervical spondylotic radicu-lopathy who underwent the Zero-P procedure were divided into two groups based on treatment methods:the control group(underwent Zero-P surgery alone,n=45)and the treatment group(received Buyang Huanwu Decoction early after Zero-P surgery for one month,n=45).The visual analog scale(VAS),cervical dysfunction index(NDI),and traditional Chinese medicine syndrome score of pain were compared between two groups before surgery and at 1 w,1 m,and 3 m after surgery.The levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)were measured and compared before surgery and at 1 w,1 m post-surgery.Re-sults:The VAS scores,NDI scores,and TCM syndrome scores of both groups at 1 w,1 m,and 3 m after surgery were lower than those before surgery(P＜0.05),and the degree of reduction increased over time(P＜0.05).The treatment group showed more significant reductions at corresponding time points compared to the control group(P＜0.05).Both groups showed decreases in TNF-α,IL-1β,and IL-6 levels at 1 w and 1 m after surgery compared to before surgery(P＜0.05),and the treatment group showed lower levels at corre-sponding time points compared to the control group(P＜0.05).Conclusion:Early application of Buyang Huanwu Decoction after Zero-P interbody fusion fixation can reduce inflammatory response,significantly improve pain,restore cervical function,and accelerate recov-ery in patients with cervical radiculopathy.