Objective:To analyze the relationship between procalcitonin(PCT)and serum amyloid A(SAA)levels and disease condition and therapeutic effect of patients with brucellosis.Methods:70 patients with brucellosis were enrolled in this study and were divided into mild group(n=34)and severe group(n=36)by means of the disease severity.All patients received standard anti-bru-cellosis treatment.The clinical data of patients with brucellosis were collected,and the levels of PCT and SAA were compared among all patients and between mild group and severe group before and after treatment.Multivariate Logistic regression analysis was used to ana-lyze the risk factors affecting the disease condition and therapeutic effect of patients.Spearman correlation analysis was applied to ana-lyze the relationship of PCT and SAA levels with disease condition and therapeutic effect.Receiver operating characteristic(ROC)curve was adopted to evaluate the predictive ability of serum PCT and SAA levels on disease condition in patients with brucellosis.Re-sults:Before treatment,the PCT and SAA levels in severe group were higher than those in mild group(P＜0.05).After treatment,the levels of PCT and SAA decreased in both groups(P＜0.05),but there was no statistically significant difference between the two groups(P＞0.05).Multivariate Logistic regression analysis indicated that serum PCT and SAA levels were independent risk factors for severi-ty of brucellosis(P＜0.05).Spearman correlation analysis suggested that serum PCT and SAA were positively correlated with brucello-sis severity(P＜0.05),and were negatively correlated with therapeutic effect(P＜0.05).ROC curve analysis showed that the AUCs of serum PCT and SAA levels in the diagnosis of disease severity of brucellosis were 0.781 and 0.866 respectively(P＜0.05).The AUC,sensitivity and specificity of combined diagnosis were 0.934,0.806 and 0.882(P＜0.05).Conclusion:The levels of PCT and SAA are closely related to the disease severity and therapeutic effect of patients with brucellosis,and can be used as important indicators to evaluate the disease condition and therapeutic effect.