< positive > 1 case data patient, female, 61 years old. He was admitted to the hospital on March 10, 2023 because of "diarrhea for 3 years and aggravated for half a year". The patient had no obvious cause of diarrhea 3 years ago, presenting yellow watery stools, no mucus, pus and blood, defecating about 10 times / D, no abdominal pain, abdominal distension, nausea and vomiting, no acid regurgitation and heartburn, and the symptoms were relieved after oral administration of "omeprazole, levofloxacin, probiotics, montmorillonite powder", but the diarrhea was repeated after discontinuation. Half a year ago, the diarrhea of the patient was more serious than before, the number of defecation increased to 10-20 times / D, accompanied by acid reflux and heartburn, and the body weight decreased by about 10 kg in recent half a year.