Objective:To investigate the clinical efficacy of Tubridge and Pipeline flow diverting devices in treating complex in-tracranial aneurysms.Methods:The clinical data of 31 patients with complex intracranial aneurysms who received Pipeline flow divert-ing device were retrospectively analyzed,and the patients were enrolled as control group.The clinical data of 29 patients who adopted Tubridge flow diverting device during the same period were selected as observation group.According to the follow-up results at 6 months after surgery,the clinical efficacy,clinical symptom relief and aneurysm occlusion(OKM classification)were evaluated.The levels of brain injury markers[serum central nerve specific protein(S100B),neuron-specific enolase(NSE)]before surgery and at 6 months after surgery,and complications were compared between the two groups.Results:There were no significant differences in clinical effec-tive rate,total relief rate of clinical symptoms,total occlusion rate of aneurysms and levels of brain injury markers between the two groups(P＞0.05).The total incidence rate of complications in observation group was lower than that in control group(P<0.05).Conclusion:The above two devices for patients with complex intracranial aneurysms can effectively relieve the clinical symptoms and accelerate the occlusion of intracranial aneurysms,but Tubridge flow diverting device can better reduce the risk of postoperative compli-cations.