Objective:To explore the efficacy of Baihe Dihuang Decoction in the treatment of perimenopausal insomnia and its effect on sex hormones.Methods:122 patients with perimenopausal insomnia were divided into control group and observation group ac-cording to different treatment methods,56 cases in each group.The control group was treated with estazolam orally,and the observation group was treated with Baihe Dihuang Decoction.Continuous medication for 1 months.The total clinical effective rate,Sleep quality[Pittsburgh Sleep Quality Index(PSQI)],menopausal symptoms[Kupperman Scale],TCM syndrome scoreand serum sex hormones[estradiol(E2),luteinizing hormone(LH),follicle stimulating hormone(FSH)]levels were compared between the two groups.Re-sults:After treatment,the levels of PSQI score,Kupperman scale score,TCM syndrome score and serum FSH in observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the levels of serum E2 and LH be-tween the two groups(P＞0.05).The observation group had lower serum FSH levels(P<0.05).The total effective rate of the obser-vation group was higher than that of the control group(91.07%vs.73.21%,P<0.05).Conclusion:Modified Baihe Dihuang Decoc-tion can improve the sleep quality and perimenopausal symptoms of perimenopausal insomnia patients,regulate the expression of sex hormones.