Objective:To explore the clinical curative effect of Liangxue Huayu Mingmu Decoction in retinal vein obstruction(RVO)combined with macular edema(ME).Methods:A total of 80 patients(80 eyes)with RVO and ME were included in the study,and they were divided into experimental group and control group according to different treatment methods,with 40 cases in each group.The control group was given intravitreal injection of ranibizumab,while experimental group was treated with Liangxue Huayu Mingmu Decoction on basis of control group for 4 weeks.The curative effect on TCM syndromes,adverse reactions during treatment and changes of visual acuity were compared between the two groups.Results:The curative effect on TCM syndromes in experimental group was better than that in control group(P<0.05).After 1,2 and 4 weeks of treatment,LogMAR,CMT and intraocular pressure in exper-imental group were lower than those in control group(P<0.05).After 4 weeks of treatment,the mean deviation of visual field and vis-ual field index in experimental group were higher than those in control group(P<0.05).There was no significant difference in the in-cidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion:Liangxue Huayu Mingmu Decoction combined with intravitreal injection of ranibizumab can improve clinical curative effect,visual acuity and visual field defect,promote ME regression and control intraocular pressure in patients with RVO and ME,which has good safety.