多模态磁共振成像对脑膜瘤分级与分型的诊断价值
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陕西省重点研发计划项目(2024SF-YBXM-085);


Diagnostic value of multimodal magnetic resonance imaging in grading and Subtype of meningiomas
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    摘要:

    目的:探讨多模态磁共振成像(MRI)对脑膜瘤分级与分型的诊断价值。方法:选取98例脑膜瘤患者为研究对象,根据病理检查结果分为良性组(n=78)和恶性组(n=20)。患者入院后均接受常规MRI扫描及多模态MRI检查。比较良性组和恶性组脑膜瘤患者、不同良性脑膜瘤亚型患者多模态MRI参数[脑膜瘤区表观弥散系数(ADC)、局部脑血流量(rCBF)、磁敏感信号强度(ITSS)、乙酰天门冬氨酸(NAA)/胆碱(Cho)、NAA/肌酸(Cr)、Cho/Cr],受试者工作特征(ROC)曲线分析多模态MRI对脑膜瘤分型分级的诊断价值。结果:恶性组患者脑膜瘤区ADC值、NAA/Cho、NAA/Cr低于良性组(P<0.05);rCBF、ITSS、Cho/Cr高于良性组(P<0.05)。ROC曲线分析显示,三维动脉自旋标记(3D-ASL)、磁共振扩散加权成像(DWI)、磁敏感加权成像(SWI)及磁共振波谱成像(1H-MRS)对脑膜瘤分级诊断的曲线下面积(AUC)为0.723、0.735、0.777、0.870,联合诊断的AUC为0.957。不同良性脑膜瘤亚型患者rCBF、ITSS、NAA/Cho、NAA/Cr及Cho/Cr水平比较,差异有统计学意义(P<0.05)。结论:多模态MRI对脑膜瘤分级与分型的鉴别与诊断具有良好的临床价值。

    Abstract:

    Objective:To analyze the diagnostic value of multimodal magnetic resonance imaging(MRI)in grading and Sub-type of meningiomas.Methods:A total of 98 patients with meningiomas were reviewed.They were divided into benign group(n=78)and malignant group(n=20)according to the pathological examination results.All of them underwent conventional MRI scan and mul-timodal MRI examination upon admission.The multimodal MRI parameters[apparent diffusion coefficient(ADC),local cerebral blood flow(rCBF),magnetic sensitive signal intensity(ITSS),N-acetylaspartate(NAA)/choline(Cho),NAA/creatine(Cr),Cho/Cr]of patients with benign and malignant meningiomas,and patients with different subtypes of benign meningiomas were compared.The diag-nostic value of multimodal MRI for meningioma classification and grading were analyzed by receiver operating characteristic(ROC)curves.Results:The ADC,NAA/Cho ratio and NAA/Cr ratio of meningiomas in the malignant group were lower than those in the be-nign group(P<0.05).The rCBF,ITSS and Cho/Cr ratio were higher than those in the benign group(P<0.05).The AUC values of three-dimensional arterial spin labeling(3D-ASL),diffusion-weighted imaging(DWI),susceptibility-weighted imaging(SWI)and proton magnetic resonance spectroscopy(1 H-MRS)for grading of meningiomas were 0.723,0.735,0.777 and 0.870.The AUC of com-bined diagnosis was 0.957.There were significant differences in rCBF,ITSS,NAA/Cho ratio,NAA/Cr ratio and Cho/Cr ratio among patients with different subtypes of benign meningiomas(P<0.05).Conclusion:Multimodal MRI is helpful in clinical grading and Subtype of meningiomas.

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冀笑笑;吕海蓉;贾荣荣;赵凤;.多模态磁共振成像对脑膜瘤分级与分型的诊断价值[J].川北医学院学报,2025,40(6):713-718.

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  • 在线发布日期: 2025-07-09
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