Objective:To investigate the efficacy of dapagliflozin combined with enalapril in the treatment of diabetic nephropa-thy(DN).Methods:A total of 160 patients with DN were divided into control group and observation group according to different treat-ment methods,with 80 cases in each group.The two groups were treated with enalapril and dapagliflozin combined with enalapril respec-tively for 12 weeks.Before and after treatment,the levels of 24 h urinary protein quantification(24 h UAE),urinary albumin to creati-nine ratio(ACR),serum creatinine(Scr),urea nitrogen(BUN)and estimated glomerular filtration rate(eGFR)were detected,and the levels of urine membrane protein(Podocin),podocyte slit diaphragm protein(Nephrin)and serum interleukin 6(IL-6),tumor necrosis factor α(TNF-α)were measured.The efficacy and adverse reactions of the two groups were compared.Results:The total ef-fective rate of the observation group was higher than that of the control group(P＜0.05).After treatment,compared with the control group,the 24 h UAE level,ACR value,Scr and BUN in the observation group decreased(P＜0.05),and the eGFR level increased(P＜0.05).The levels of urinary Podocin,Nephrin,serum IL-6,and TNF-α in the observation group were lower than those in the con-trol group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Dapagliflozin combined with enalapril can more effectively reduce proteinuria,improve renal function and im-prove the efficacy of DN.The mechanism may be related to inhibiting inflammation and alleviating podocyte injury.