Objective:To investigate the clinical effect of periodontal therapy+orthodontic+implant in the treatment of denti-tion defect.Methods:84 patients with dentition defect were included and divided into two groups according to different treatment meth-ods,with 42 cases in each group.The control group received conventional treatmen,and the observation group was treated with periodon-tal therapy+orthodontic+implant multidisciplinary treatment.The clinical efficacy,lateral skull X-ray measurement results[the dis-tance from the upper dental groove seat point to the maxillary plane(A-PFP),the distance from the lower dental groove seat point to the maxillary plane(B-PFP),the angle between the anterior skull base plane and the mandibular plane(SN-OP),the angle between the orbital ear plane and the mandibular plane(FH-MP),the distance from the upper dental groove edge point to the submental point(ANS Me),the distance from the upper lip protrusion point to the aesthetic line(Ls-E line),and the distance from the lower lip pro-trusion point to the aesthetic line(Li-E line)]and tooth function(self-made dental function score)were compared between the two groups.Results:The total effective rate of observation group was higher than that of control group(P＜0.05).After treatment,there was a statistically significant difference in the changes of A-PFP,SN-OP,FH-MP,ANS-Me and Ls-E lines between the two groups(P＜0.05),and the scores of mastication,pronunciation and swallowing in the observation group were higher than those in the control group(P＜0.05).Conclusion:The combination of periodontal therapy+orthodontic+implant can improve the clinical effect and improve the dental function of patients with dental defects.