Objective:To explore the effects of batroxobin injection combined with enteric-coated aspirin on coagulation func-tion,inflammatory response,and symptoms in patients with deep vein thrombosis following lower limb fractures during the acute phase.Methods:A total of 108 patients with lower limb fractures complicated by deep vein thrombosis were divided into a control group and an observation group according to different treatment methods,with 54 cases in each group.The control group received treatment with enter-ic-coated aspirin,while the observation group received batroxobin injection in addition to aspirin treatment,lasting for 7 days.Both groups continued treatment with enteric-coated aspirin for 7 months to consolidate the therapeutic effect.After 7 days of treatment,the efficacy,coagulation function,blood rheology,inflammation,venous blood flow velocity,lower limb circumference,pain[Visual Analog Scale(VAS)],lower limb symptoms,and incidence of adverse reactions were recorded and compared between the two groups.Results:The effective rate of treatment in the observation group was higher than that in the control group(92.59%vs.77.78%,P＜0.05).Af-ter treatment,the activated partial thromboplastin time(APTT)in the observation group was higher than that in the control group(P＜0.05),while fibrinogen(FIB),prothrombin time(PT),whole blood high shear viscosity,and whole blood low shear viscosity levels were all lower than those in the control group(P＜0.05).Additionally,levels of hypersensitive C-reactive protein(hs-CRP),procalci-tonin(PCT),and interleukin-6(IL-6)in the observation group were lower than those in the control group(P＜0.05).The venous blood flow velocity in the observation group was higher than that in the control group(P＜0.05),and the lower limb circumference,VAS score,lower limb swelling,skin color,and cord-like or nodular scoring were all lower than those in the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:For pa-tients with deep vein thrombosis following lower limb fractures,the short-term efficacy of batroxobin injection combined with enteric-coated aspirin is significant,beneficial for improving coagulation function and blood rheology indicators during the acute phase,and helps reduce inflammation and pain levels,effectively improving lower limb symptoms.It is worthy of clinical promotion and application.