Objective:To explore the effects of different pneumoperitoneum pressures on intraoperative hypothermia,stress re-sponse and postoperative recovery in patients undergoing laparoscopic total hysterectomy.Methods:A total of 80 patients with laparo-scopic total hysterectom were divided into low pressure group and high pressure group accordingto to the given pneumoperitoneum pres-sure,with 40 cases in each group.The pneumoperitoneum pressure of the low pressure group and the high pressure group was 12 mmHg and 14 mmHg,respectively.The body temperature[core body temperature before pneumoperitoneum(T0),10 min after pneumoperito-neum(T1),20 min after pneumoperitoneum(T2),30 min after pneumoperitoneum(T3),5 min after operation(T4),incidence of hy-pothermia],postoperative recovery[anesthesia recovery time,extubation time],stress response[serum norepinephrine(NE),cortisol(Cor)levels at T0,T1,T2,T3 and T4]and postoperative recovery were compared between the two groups.Results:The core body tem-perature at T1～T4 in the low pressure group was higher than that in the high pressure group(P＜0.05).Theincidenceof hypothermia in the low pressure group was lower than that in the high pressure group(P＜0.05).The levels of NE and Cor in the low pressure group were lower than those in the high pressure group at T1～T4(P＜0.05).The anesthesia recovery time,extubation time,the first exhaust,defecation and hospitalization time in the low-pressure group were shorter than those in the high-pressure group(P＜0.05).Conclusion:The establishment of pneumoperitoneum with 12 mmHg and 14 mmHg pressure in laparoscopic total hysterectomy can en-sure the smooth development of the operation.When low CO2 pressure(12 mmHg)is used to establish pneumoperitoneum during oper-ation,it can slow down the decrease of body temperature,reduce the incidence of hypothermia,promote postoperative recovery,and have less stress response,which is more conducive to postoperative recovery.