Objective:To explore the effect of multi-disciplinary combined prosthesis in the treatment of anterior tooth defect im-plantation and its impact on oral function.Methods:300 patients with anterior tooth defect implantation and repair were included as the study objects,and were evenly divided according to different treatment methods,with 150 cases in each group.The control group re-ceived conventional repair treatment,and the observation group received oral multidisciplinary combined repair treatment,both groups were followed up for 6 months.The aesthetic effects[Red Aesthetics Index(WES)and White Aesthetics Indes(PES)scores],oral function scores(language and chewing function,tooth mobility scores),levels of inflammatory factors[tumor necrosis factor alpha(TNF-α),interleukin-10(IL-10),and IL-6],and incidence of complications before and 6 months after treatment were compared be-tween the two groups.Results:The aesthetic effect scores of WES and PES in observation group were higher than the control group(P＜0.05).After treatment,the masticatory and language function scores in the observation group were higher than the control group,and the tooth mobility score score was lower than the control group(P＜0.05).After treatment,the levels of TNF-α,IL-10,IL-6,and total incidence of complications in the observation group were lower than those in the control group(P＜0.05).Conclusion:The effect of multi-disciplinary dental joint repair is obvious in patients with anterior tooth defect implantation,which can guarantee the oral aes-thetic effect,improve the oral function and effectively prevent complications,and can be widely used in clinic.