Objective:To investigate the effect of endoscopic rotatable repeated opening and closing soft tissue clip or metal tita-nium clip combined with local application of hemocoagulase in treating upper gastrointestinal bleeding(UGIB).Methods:The clinical data of 97 patients with UGIB were retrospectively analyzed.The enrolled patients were classified into soft tissue clip group(n=51)and metal titanium clip group(n=46)by adopting different endoscopic hemostatic clips.The soft tissue clip group was given endoscop-ic rotatable repeated opening and closing soft tissue clip,while the metal titanium clip group was treated with endoscopic metal titanium clip,and the patients of both groups were treated with gastric tube perfusion with 1 mL serrapeptide hemocoagulase mixed with 10 mL of physiological saline.The hemostatic effect,surgical related indexes,recovery conditions and blood related indexes before and after treat-ment were compared,and the incidence rates of complications in the two groups were counted.Results:The rebleeding rate in soft tissue clip group was better than that in metal titanium clip group(P＜0.05).The number of hemostatic clips used,intraoperative blood loss,hemostatic clip shedding time and hospital stay were better in soft tissue clip group than those in metal titanium clip group(P＜0.05).There was no statistically significant difference in surgical reoperation rate and recovery between the two groups(P＞0.05).After treat-ment,the platelet aggregation rate,hemoglobin and fibrinogen in the two groups were risen(P＜0.05),and the indexes in soft tissue clip group were higher than those in metal titanium clip group(P＜0.05).There was no statistically significant difference in the total incidence of complications between the two groups(P＞0.05).Conclusion:Endoscopic rotatable repeated opening and closing soft tis-sue clip is more effective in the treatment of UGIB.It has better hemostatic effect,slightly lower complications and surgical reoperation rate than metal titanium clip.