Objective:To explore the predictive value of transferrin receptor 1(CD71)and procalcitonin(PCT)in the short-term prognosis of patients with septic shock.Methods:150 patients with septic shock were selected as the research objects.According to the survival of patients 28 days after treatment,they were divided into survival group(n=89)and death group(n=61).Within 8 hours after admission,serum CD71,PCT and other laboratory indicators were measured in all patients.The differences were compared between the two groups of indicators.Logistic regression analysis was used to screen the influencing factors of prognosis,and the predic-tive value of each index for prognosis was evaluated by receiver operating characteristic curve(ROC).Results:A total of 150 cases were included,61 cases(40.67％,death group)died at 28 days,and 89 cases(59.33％,survival group)survived.Compared with the survival group,the patients in the death group had a greater age(P<0.05),a higher APACHE Ⅱ score(P<0.05),and serum PCT and CD71 levels were also increased(P<0.05).Multivariate Logistic regression analysis showed that APACHE Ⅱ score(OR=1.196),age(OR=1.068),PCT(OR=1.217)and CD71(OR=1.239)were independent factors affecting the short-term prognosis of patients with septic shock(P<0.05).Pearson correlation analysis showed that PCT(r=1.181)and CD71(r=0.236)were posi-tively correlated with APACHE Ⅱ score(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of APACHE Ⅱ score,PCT and CD71 were 0.686,0.842 and 0.852,respectively.The AUC of PCT combined with CD71 was 0.930,the sensitivity and specificity were 86.89％and 89.89％,respectively.Conclusion:Both CD71 and PCT can be used to predict the short-term prognosis of patients with septic shock,and the predictive value of CD71 combined with PCT is higher than that of single application.