Objective:To investigate the correlation between serum C-reactive protein(CRP),serum uric acid(SUA),25-hydroxyvitamin D[25(OH)D]and sarcopenia in elderly type 2 diabetes mellitus(T2DM)patients.Methods:A total of 122 elderly patients with T2DM were divided into simple T2DM group(n=94)and sarcopenia group(n=28).The differences of serum CRP,SUA,25(OH)D and other laboratory indexes between the two groups were compared.The factors that affect the occurrence of sarcope-nia in elderly T2DM patients were analized by Logistic regression analysis.The diagnostic value of each index for sarcopenia was evalua-ted by receiver operating characteristic(ROC)curve.Results:Compared with the simple T2DM group,the sarcopenia group had a higher proportion of males(P<0.05),older age(P<0.05),and lower BMI level(P<0.05).Compared with the simple T2DM group,the levels of serum HbA1 c and CRP in the sarcopenia group were increased,and the levels of 25(OH)D and SUA were de-creased(P<0.05).Logistic regression analysis showed that age(OR=1.143)and serum CRP(OR=1.095)were risk factors for sarcopenia in elderly T2DM patients(P<0.05),while SUA(OR=0.956)and 25(OH)D(OR=0.941)were protective factors(P<0.05).ROC curve analysis showed that serum CRP,SUA and 25(OH)D levels had certain diagnostic value for T2DM combined with sarcopenia in the elderly,and their AUC were 0.718,0.716 and 0.743,respectively.Conclusion:The levels of serum CRP,SUA and 25(OH)D in elderly patients with T2DM are closely related to the occurrence of sarcopenia.The increase of CRP level and the decrease of SUA and 25(OH)D levels may indicate a higher risk of sarcopenia.