妊娠合并子宫肌瘤发生不良妊娠结局的相关影响因素
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吴阶平医学基金会临床科研专项资助基金(320.6750.2021-25-5);


Influencing factors of adverse pregnancy outcomes associated with uterine fibroids in pregnancy
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    摘要:

    目的:探讨妊娠合并子宫肌瘤发生不良妊娠结局的相关影响因素。方法:选取128例妊娠合并子宫肌瘤的患者为研究对象,根据妊娠结局分为不良妊娠结局组(n=50)和无不良妊娠结局组(n=78)。单因素和多因素Logistic回归分析影响妊娠合并子宫肌瘤发生不良妊娠结局的相关因素。结果:128例妊娠合并子宫肌瘤患者中,发生不良妊娠结局50例,占比39.0%。单因素分析结果显示,两组患者分娩孕周、年龄、产次、瘢痕子宫、剖宫产率、子宫肌瘤直径≥7 cm比较,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,子宫肌瘤直径≥7 cm(OR=0.333,95%CI=0.126~0.882,P=0.027)、低剖宫产率(OR=7.324,95%CI=2.153~24.918,P=0.001)是妊娠合并子宫肌瘤患者发生不良妊娠结局的危险因素。结论:较大的子宫肌瘤是发生不良妊娠结局的危险因素,临床上应加强子宫肌瘤患者产检及危险因素的监测,预防孕产妇不良妊娠结局的发生。

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    Objective:To explore the relevant influencing factors of adverse pregnancy outcomes in pregnancies complicated with uterine fibroids.Methods:A total of 128 patients with pregnancy complicated with uterine fibroids were selected as the research sub-jects.Based on the occurrence of adverse pregnancy outcomes,they were divided into an adverse pregnancy outcome group(n=50)and a non-adverse pregnancy outcome group(n=78).Univariate and multivariate Logistic regression analyses were conducted to ana-lyze the relevant influencing factors of adverse pregnancy outcomes in pregnant women with uterine fibroids.Results:Among 128 cases of pregnancy complicated with uterine fibroids,50 cases had adverse pregnancy outcomes,accounting for 39.0%.Univariate analysis showed that there were statistically significant differences between the adverse pregnancy outcome group and the non-adverse pregnancy outcome group in terms of gestational week at delivery,age,number of deliveries,history of cesarean section,cesarean section rate,and uterine fibroid diameter≥7 cm(P<0.05).Multivariate Logistic regression analysis indicated that a uterine fibroid diameter≥7 cm(OR=0.333,95%CI=0.126~0.882,P=0.027)and a low cesarean section rate(OR=7.324,95%CI=2.153~24.918,P=0.001)were risk factors for adverse pregnancy outcomes in patients with pregnancy complicated by uterine fibroids.Conclusion:Larger uterine fibroids are a risk factor for adverse pregnancy outcomes.Clinically,it is important to strengthen prenatal care and monitoring of risk factors in patients with uterine fibroids to prevent adverse pregnancy outcomes in pregnant women.

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夏宗燕;田华东;汪国娇;罗岳西;.妊娠合并子宫肌瘤发生不良妊娠结局的相关影响因素[J].川北医学院学报,2025,40(8):1021-1024.

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