Objective:To investigate the efficacy of dorsal root ganglion pulsed radiofrequency(PRF)combined with ozone or platelet-rich plasma(PRP)in the treatment of postherpetic neuralgia(PHN).Methods:60 patients with thoracic PHN were selected as the research subjects,and were divided into PRP group(n=30)and ozone group(n=30)according to different treatment meth-ods.The PRP group received PRF combined with PRP treatment,while the ozone group received PRF combined with ozone treatment.The differences in pain levels[Visual Analog Scale(VAS)],infrared thermography temperature difference,and sleep quality[Pitts-burgh Sleep Quality Index(PSQI)]between two groups of patients before and after treatment(7 days and 1 month,3 months,6 months),the differences in levels of pain mediators and inflammatory factors before and 3 months after treatment were compared be-tween the two groups.Results:At different time points after treatment,the VAS score,infrared thermal imaging temperature difference and PSQI of both groups decreased over time,and the PRP group was lower than the ozone group(P<0.05).At6 months after treat-ment,the VAS scores,infrared thermal imaging temperature difference and PSQI in the PRP group decreased compared to 3 months(P<0.05),and the PRP group was lower than the ozone group(P<0.05).The levels of β-endorphin in the PRP group were higher than those in the ozone group(P<0.05),while the levels of substance P,prostaglandin E2,and inflammatory factors in the PRP group were lower than those in the ozone group(P<0.05).Conclusion:Compared with ozone combined with PRF,PRP combined with PRF can achieve a more sustained therapeutic effect on patients with PHN,and has a better effect on improving sleep quality.