Objective:To investigate the mediating pathways through which family empowerment impacts family resilience in first-episode stroke patients.Methods:312 first-episode stroke patients and corresponding caregivers admitted from February 2024 to July 2024 were included as the research subjects.Clinical data,coping styles,self-efficacy,family resilience,and family empowerment were evaluated using questionnaires,Simple Coping Styles Scale,General Self-efficacy Scale,Family Resilience Scale,and Main Care-givers Empowerment.Pearson and Structural Equation Models were used to analyze the relationship between family empowerment and family resilience.Results:There was no statistically significant difference in family resilience scores among patients with first stroke from different age,gender,body mass index,marital status,disease type,time of onset to visit time(P>0.05),patients with severe dys-function showed lower family resilience scores compared to those with mild or no dysfunction(P<0.05).There was no significant difference in the family resilience scores of first-time stroke caregivers with different ages,genders,marital status,and education levels(P>0.05),the family resilience scores of first-time stroke caregivers with chronic diseases were lower than those without chronic dis-eases(P<0.05).Correlation analysis showed that positive coping styles,self-efficacy,and family empowerment showed positive corre-lations with family resilience(P<0.05),while negative coping styles were negatively correlated with family resilience(P<0.05).Structural model fitting indicators χ2/df=2.522,RMSEA=0.070,TLI=0.932,CFI=0.944,Bootstrap program test showed that family empowerment could directly affect family resilience,and could also affect family resilience through self-efficacy and coping styles.Con-clusion:In clinical recovery from first stroke,attention should be paid to the effect of family empowerment between different action paths,and reasonable intervention methods should be adopted based on the paths to improve the resilience of family stroke patients.