Objective:To explore the correlation between the onset of osteoporosis(OP)and the levels of blood lipids,blood glucose and serum uric acid.Methods:The clinical data of 447 patients who came to our hospital for bone mineral density(BMD)screening were retrospectively analyzed,and they were divided into osteoporosis group(n=119)and non-osteoporosis group(n=328)according to the results of BMD T-value.The general data,lumbar spine(L,-L4)BMD,uric acid(UA),blood glucose(GLU),blood lipid and other index levels and their correlation with OP were compared between the two groups.Re-sults:There were statistically significant differences in gender,L-L4 bone mineral density,uric acid,fasting blood glucose,and total cholesterol between the two groups.Multivariate Logistic regression analysis showed that total cholesterol,uric acid,fast-ing blood glucose were independent risk factors for OP.The receiver operating characteristic(ROC)curve analysis showed that UA,fasting GLU and total cholesterol had certain predictive value for the occurrence of OP,and the combined performance of the three had a higher efficacy.Conclusion:In the risk of OP,total cholesterol,UA,and fasting GLU are independent risk fac-tors,and the combination of these indicators has a higher predictive power for OP.