Objective:To investigate the effects of piperazine ferulate combined with prednisone on immunoglobulins,bone metabolism and lipids in patients with nephrotic syndrome.Methods:120 patients with nephrotic syndrome were included as study subjects,grouped according to the actual treatment,divided into the control group(prednisone treatment)and the combi-nation group(combined with ferulic acid piperazine treatment on the basis of the control group),60 cases in each group.The treatment efficiency,immunoglobulin A(IgA),immunoglobulin G(IgG),immunoglobulin M(IgM),glutamic transaminase(AST),blood creatinine(SCr),blood urea nitrogen(BUN),24 h urine protein volume,parathyroid hormone(PTH),osteocal-cin(BGP),25-hydroxyvitamin D,total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),and the incidence of adverse reactions were recorded and compared between the two groups.Results:The efficacy rate of the observation group was higher than that of the control group(P＜0.05).After treat-ment,compared with the control group,the observation group showed higher levels of IgA,IgG,IgM,BGP,25-hydroxyvitamin D,and HDL-C(P＜0.05),and lower levels of SCr,BUN,24 h urinary protein,PTH,TC,TG,and LDL-C(P＜0.05).There were no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclu-sion:The combination of ferulic acid piperazine and prednisone is beneficial for regulating immune function in patients with ne-phrotic syndrome,helps improve bone metabolism disorders and kidney function,and reduces patients'blood lipid levels.It has a good safety profile and demonstrates significant overall therapeutic efficacy.