Objective:To explore the efficacy of dydrogesterone and norethindrone on pain relief and clinical symptom im-provement in patients with endometrial polyps.Methods:The clinical data of 98 patients with endometrial polyps were retro-spectively analyzed.They were divided into Group A(n=31,dydrogesterone),Group B(n=33,norethindrone),and Group C(n=34,dydrogesterone+norethindrone)according to different treatment methods.The clinical efficacy,pain,clinical symp-toms(vaginal bleeding time,endometrial thickness,menstrual flow),adverse reactions and recurrence were compared among the three groups.Results:The total clinical efficacy rate after treatment in group A was 74.19％,and the total efficacy rate in group B was 75.76％,and there was no significant difference in the comparison between the groups(P＞0.05),the total effica-cy rate after treatment in group C was 97.06％,which was significantly higher than that in groups A and B(P＜0.05).The VAS scores of pelvic pain,dysmenorrhea and dyspareunia were lower than those before treatment in all three groups,and the a-bove scores were lower than those in Groups A and B after treatment in Group C(P＜0.05).However,there was no significant difference in the comparison of the above scores after treatment in groups A and B(P＞0.05).Endometrial thickness and men-strual flow were lower in the three groups after treatment than before treatment,and endometrial thickness and menstrual flow was less in Group C than in Groups A and B,and the vaginal bleeding time was shorter than in Groups A and B(P＜0.05),there were no significant differences in the above indicators between groups A and B after treatment(P＞0.05).There was no statistically significant difference in the total incidence of adverse reactions among the groups(P＞0.05).The recurrence rate of group C was 2.94％,which was significantly lower than that of groups A and B(P＜0.05).Conclusion:Dydrogesterone and no-rethindrone can be effective in treating endometrial polyps,but the combined treatment of the two is more effective,which is more helpful in relieving the pain of the patients,improving the endometrial condition,shortening the time of vaginal bleeding,and decreasing the recurrence rate of the disease.