Objective:To explore the therapeutic effect of myofascial stretch relaxation exercise(MSRE)combined with occupational therapy(OT)on children with spastic cerebral palsy(SCP).Methods:100 children with SCP were divided into OT group and combined group according to different methods,with 50 cases in each group.OT group adopted OT,and com-bined group was treated with MSRE combined with OT,and the treatment period was 8 weeks.The total effective rate of upper limb muscle tension improvement was evaluated in OT group and combined group after treatment.The changes in joint passive range of motion(PROM),development quotient(DQ),gross motor function(GMFM88)development ability evaluation,lan-guage development ability evaluation and upper limb fine motor function measure(FMFM)before and after treatment were an-alyzed.Results:After treatment,the PROM values at various parts,DQ values at 5 energy zones,GMFM88 evaluation,language development ability evaluation and 5 test scores of FMFM ability in OT group and combined group were higher than those be-fore treatment(P＜0.05),and the scores in combined group were higher than those in OT group after treatment(P＜0.05).After treatment,the 10 m walking test(10MWT)time was shorter in OT group and combined group than that before treat-ment,and the combined group had shorter 10MWT time(P＜0.05).The total effective rate of upper limb muscle tension im-provement after treatment in combined group was 90.00％,which was higher than 56.00％in OT group(P＜0.05).Conclu-sion:MSRE combined with OT can improve PROM value,DQ value,motor development ability,language development ability,muscle tension and upper limb fine motor function in children with SCP,and it is of positive significance for the prognosis and rehabilitation.