Objective:To explore the influence of local infiltration of bupivacaine liposome on pain and accelerated rehabili-tation effect after total hip arthroplasty(THA).Methods:80 patients who were scheduled to undergo THA were divided into two groups according to different analgesic methods,with 40 cases in each group.The control group and the study group were treated with 100 mg of ropivacaine+0.1 mg of epinephrine+5 mg of dexamethasone and bupivacaine liposome solution for local infiltration analgesia respectively.The postoperative recovery conditions were compared between groups.Results:The pain visual analogue scale(VAS)scores in resting state at different time points after surgery were lower in the study group than those in the control group(P＜0.05),and the dosage of postoperative remedy tramadol was less(P＜0.05),and the time of postoperative first remedy tramadol was later compared with that in the control group(P＜0.05).The QoR scores in the study group at 24,48 and 72 hours after surgery were higher(P＜0.05),and the postoperative hospital stay was shorter compared to the control group(P＜0.05).There was no statistically significant difference in in the incidence rates of adverse reactions be-tween the two groups(P＞0.05).Conclusion:Local infiltration of bupivacaine liposome can alleviate the pain of patients after THA,reduce the use of opioids,and promote the early postoperative health recovery of patients.