Objective:To investigate the changes in coagulation function,inflammatory factors and blood lipid levels in pa-tients with type 2 diabetes mellitus(T2DM)and hyperlipidemic acute pancreatitis(HEAP)and their clinical significance.Methods:95 patients with T2DM combined with HEAP were selected and divided into mild group(n=55)and moderate group(n=40)according to the severity of their condition.The coagulation function indicators,inflammatory factors,and blood lipid levels of all patients were detected and compared.Multivariate logistic regression analysis was used to identify the risk factors for worsening the condition of T2DM combined with HEAP patients.Results:There was a statistically significant difference in the levels of triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),and fibrinogen(Fib)between the mild and mod-erate groups(P＜0.05).Multivariate Logistic regression analysis confirmed that TG,LDL-C,and Fib were risk factors for worsening the condition of T2DM patients with HEAP(P＜0.05).The areas under the curve(AUC)of receiver operating characteristic(ROC)curve analysis for predicting disease progression in T2DM patients with HEAP using TG,LDL-C,and Fib were 0.957,0.865,and 0.853,respectively.Conclusion:Changes in coagulation function and blood lipid levels in patients with T2DM and HLAP have certain impact on condition.TG,LDL-C,and Fib can be taken as key monitoring indicators to help time-ly evaluate the severity of the disease and formulate or adjust clinical treatment plans,thus improving the prognosis.