Objective:To explore the clinical effect of meticulous capsular dissection technique combined with exposure of recurrent laryngeal nerve(RLN)through cricothyroid space on patients with thyroid carcinoma(TC).Methods:80 patients with TC in the hospital were retrospectively selected,and they were treated with total thyroidectomy(TT).According to the RLN anatomy and exposure scheme adopted during surgery,the above patients were divided into two groups.38 patients in the control group were treated with traditional surgery+arterial exposure of RLN,and the remaining 42 patients in the study group received meticulous capsular dissection+cricothyroid space exposure of RLN.Perioperative conditions,parathyroid func-tion indicators[serum phosphorus,serum calcium,parathyroid hormone(PTH)],complications,quality of life[University of Washington Quality of Life Questionnaire(UW-QOL)]scores and long-term prognosis were compared between the two groups.Results:There were no significant differences in surgical time,intraoperative blood loss and number of lymph node dis-section between the two groups(P＞0.05).At 7 days after surgery,serum phosphorus in the two groups was enhanced com-pared with that before surgery while serum calcium and PTH were reduced compared to before operation(P＜0.05).Com-pared with the control group,serum phosphorus in the study group was lower while serum calcium and PTH were higher(P＜0.05).The study group had lower incidence of postoperative complications than the control group(P＜0.05).At 30 days after surgery,the UW-QOL scores were higher in the study group than those in the control group(P＜0.05).There was no signifi-cant difference in the recurrence rate between both groups after 24 months of follow-up(P＞0.05).Conclusion:Meticulous cap-sular dissection technique+cricothyroid space exposure of RLN has a more significant surgical effect in the treatment of dif-ferentiated TC,and it can effectively protect the parathyroid gland,reduce the occurrence of postoperative complications and im-prove the quality of life.