Objective:To investigate the application effect of anti-vascular endothelial growth factor(VEGF)drugs in the treatment of exudative age-related macular degeneration.Methods:The clinical data of 110 patients with monocular exudative age-related macular degeneration were retrospectively analyzed.According to different medications,they were divided into con-bercept group(n=57,intravitreal injection of conbercept)and ranibizumab group(n=53,intravitreal injection of ranibizum-ab).The efficacy,ocular hemodynamics,OCT parameters and complications were compared between the two groups.Results:The total effective rate of treatment was 98.25%in conbercept group,which was higher than 88.68%in ranibizumab group(P<0.05).Compared with ranibizumab group,the PSV and EDV of central retinal artery and ocular artery and blood flow density of choroidal capillary layer in conbercept group were higher after treatment(P<0.05).The central macular thickness was thinner in conbercept group than that in ranibizumab group after treatment(P<0.05).There was no statistical difference in the total incidence rate of complications between groups(P>0.05).Conclusion:Anti-VEGF drugs can effectively treat exu-dative age-related macular degeneration.Conbercept has better efficacy,and it can better improve the ocular hemodynamics,cen-tral macular thickness and choroidal capillary layer blood flow density,with safety.