Objective:To investigate the effects of metoprolol combined with aspirin on myocardial salvage and early major adverse cardiovascular events(MACE)in patients undergoing percutaneous coronary intervention(PCI)for acute myocardial infarction.Methods:120 patients with acute myocardial infarction were selected and divided into a control group and an observa-tion group based on the order of admission,with 60 cases in each group.Both groups received PCI treatment,the control group was given aspirin orally,while the observation group was given metoprolol combined with aspirin oral administration.The echo-cardiographic indicators,serum brain natriuretic peptide(BNP)and troponin I(cTnI)levels,coagulation function indicators[prothrombin time(PT),activated partial thromboplastin time(APTT)],myocardial salvage status,and MACE occurrence within 30 days after PCI were compared before and after treatment in both groups.Results:After treatment,the left ventricular ejection fraction(LVEF)of both groups increased,while the left ventricular end-diastolic diameter(LVEDD)and left ventricu-lar end-systolic diameter(LVESD)decreased(P<0.05).The improvement in these indicators was more significant in the ob-servation group compared to the control group(P<0.05).After treatment,the serum BNP and cTnI levels in both groups de-creased,with the observation group showed lower levels than the control group(P<0.05).After treatment,the prothrombin time(PT)and activated partial thromboplastin time(APTT)in both groups were prolonged(P<0.05),with the observation group had a longer APTT than the control group(P<0.05).There was no significant difference in the volume of edematous myocardium between the two groups(P>0.05),but the salvageable myocardial volume and microscopically visible myocardial salvage index(MSI)in the observation group were greater than those in the control group(P<0.05).The early MACE inci-dence in the observation group was lower than that in the control group(P<0.05).Conclusion:Metoprolol combined with aspi-rin can effectively improve the myocardial salvage effect in patients undergoing PCI for acute myocardial infarction,reduce the early MACE incidence,and positively impact patient outcomes.