Objective:To explore the curative effect of clean-up treatment under otoendoscope combined with bifonazole cream in fungal otitis externa(FOE).Methods:According to different treatment methods,102 patients with FOE were divided into control group(clean-up treatment under otoendoscope combined with triamcinolone acetonide and econazole cream)and study group(clean-up treatment under otoendoscope combined with bifonazole cream),51 cases in each group.The curative effect,symptoms improvement,fungal clearance rate,incidence of adverse reactions and recurrence rate at different time points were compared between the two groups.Results:After treatment,total response rate and negative conversion rate of fungi in study group were higher than those in control group(P<0.05).The scores of symptom(ear pruritus,hearing loss,tinnitus and earache),positive rates of Aspergillus and Candida,incidence of adverse reactions and recurrence rates at 4 and 8 weeks af-ter withdrawal in study group were lower than those in control group(P<0.05).There was no significant difference in recur-rence rate between study group and control group at 2 weeks after withdrawal(4.00%vs.10.53%,P>0.05).Conclusion:Clean-up treatment under otoendoscope combined with bifonazole cream can improve curative effect in FOE patients and is wor-thy of clinical promotion and application.