Objective:To investigate the therapeutic effect of compound Xueshuantong capsule combined with calcium do-besilate capsule in the treatment of non-proliferative diabetic retinopathy(DR).Methods:A total of 90 patients with non-prolif-erative DR were divided into control group and observation group according to different treatment methods,with 45 cases in each group.The two groups were treated with calcium dobesilate capsules and compound Xueshuantong soft capsules combined with calcium dobesilate capsules,respectively,for 12 weeks.Before and after treatment,the best corrected visual acuity(BC-VA),fundus hemorrhage area,fundus exudation area,number of retinal microaneurysms and central macular thickness(CMT)were detected,and the severity of diabetic retinopathy(DRSS)and TCM syndrome score were evaluated.The difference of cur-ative effect between the two groups was compared.Results:Compared with the control group,the total effective rate of the ob-servation group was higher(80.00%vs.60.00%),and the difference was significant(P<0.05).After treatment,compared with the control group,the BCVA of the observation group was higher(P<0.05),the fundus hemorrhage,exudation area,CMT,DRSS score and TCM syndrome score were lower(P<0.05),and the number of retinal microaneurysms was less(P<0.05).After treatment,the levels of serum VEGF and ET-1 in the observation group were lower than those in the control group(P<0.05).Conclusion:Calcium dobesilate capsule combined with compound Xueshuantong soft capsule in the treatment of non-proliferative DR can improve the curative effect,improve the visual acuity of patients,reduce microvascular injury and fun-dus pathological changes such as hemorrhage and exudation.