Objective:To explore on the therapeutic effect of rivaroxaban and dabigatran on left ventricular thrombus(LVT)patients after acute myocardial infarction(AMI).Methods:129 post AMI LVT patients who underwent emergency per-cutaneous coronary intervention(PCI)were divided into three groups according to different treatment methods:warfarin group(initial dose 2.5 mg,once a day,adjusted according to international standard ratio),rivaroxaban group(10 mg,once a day),and dabigatran group(110 mg,twice a day),with 43 patients in each group.The LVT dissolution rate,incidence rates of major ad-verse cardiovascular events(MACE),incidence rates of bleeding events,myocardial enzyme spectrum indexes[creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),troponin Ⅰ(cTnⅠ)]and liver function indexes were compared among the three groups of patients within 3 months.Results:The dissolution rate of LVT in rivaroxaban group and dabigatran group was higher than that in warfarin group(P<0.05).The incidence rates of MACE were lower in rivaroxaban group and dabigatran group than those in warfarin group(P<0.05),but there were no statistical differences between rivaroxaban group and dabigat-ran group(P>0.05).The total incidence rate of bleeding events in rivaroxaban group and dabigatran group was lower com-pared with that in warfarin group(P<0.05).After 7 days and 1 month of treatment,the myocardial enzyme spectrum indexes such as CK-MB,LDH and cTnⅠ were lower in rivaroxaban group and dabigatran group compared to warfarin group(P<0.05),but no statistical differences were shown between rivaroxaban group and dabigatran group(P>0.05).The differences in liver function indexes such as ALT,AST and TB were not statistically significant among the three groups of patients at each time point before and after treatment(P>0.05).Conclusion:Rivaroxaban and dabigatran are equally effective in treating LVT pa-tients after AMI,and both are superior to warfarin.Both drugs can promote LVT dissolution,reduce the risk of MACE and bleeding events,promote myocardial function recovery,and have good treatment safety.