Objective:To explore the effect of intervention model based on self-efficacy theory on self-efficacy,anxiety and depression and cancer-related fatigue in patients with thyroid cancer after operation.Methods:100 patients with thyroid cancer were divided into control group and observation group according to different intervention methods,50 cases in each group.The control group received routine nursing intervention,and the observation group received nursing intervention based on self-effica-cy theory,all of which lasted until 3 months after discharge.The scores of cancer self-management efficacy scale(SUPPH),self-rating anxiety scale(SAS),self-rating depression scale(SDS),cancer-related fatigue scale(CFS)and cancer quality of life core scale(QLQ-C30)were compared between the two groups before and after intervention.Results:After intervention,com-pared with the control group,the scores of SUPPH and QLQ-C30 in the observation group were higher(P<0.05),and the scores of SAS,SDS and CFS were lower(P<0.05).Conclusion:The intervention model based on self-efficacy theory can im-prove the patients? self-efficacy level who with thyroid cancer after operation,reduce the level of anxiety,depression and cancer-related fatigue,and improve their quality of life.