支气管镜肺泡灌洗辅助治疗小儿重症肺炎支原体肺炎疗效及对外周血CRP、PCT水平的影响
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R725.6

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宁夏自然科学基金项目(2023AAC03550);


Efficacy of bronchoscopic alveolar lavage as an adjuvant therapy for se-vere Mycoplasma pneumoniae pneumonia in children and the impact on peripheral blood CRP and PCT levels
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    摘要:

    目的:探究支气管镜肺泡灌洗疗法作为辅助手段对小儿重症肺炎支原体肺炎(SMPP)临床疗效的影响,并分析该疗法对外周血C反应蛋白(CRP)、降钙素原(PCT)水平的影响。方法:选取160例SMPP患儿为研究对象,将其按照治疗方案不同分为对照组及观察组,每组各80例,对照组实施常规治疗;观察组在常规治疗基础上辅助支气管镜肺泡灌洗。对比两组临床症状持续时间、临床疗效及外周血CRP、PCT水平,并统计并发症发生情况。结果:在临床症状持续时间方面,观察组较对照组更短(P<0.05)。相较于对照组,观察组临床总有效率更高,差异有统计学意义(P<0.05)。与治疗前比较,两组治疗2周后外周血CRP、PCT水平均下降(P<0.05);且观察组低于对照组(P<0.05)。观察组并发症总发生率(3.75%)较对照组(12.50%)更低(P<0.05)。结论:支气管镜肺泡灌洗作为小儿SMPP的辅助治疗手段,疗效明显,使各项临床症状持续时间缩短,且降低外周血CRP、PCT水平及并发症发生风险。

    Abstract:

    Objective:To investigate the clinical efficacy of bronchoscopic alveolar lavage as an adjuvant therapy for severe Mycoplasma pneumoniae pneumonia(SMPP)in children,and analyze its impact on peripheral blood C-reactive protein(CRP)and procalcitonin(PCT)levels.Methods:A total of 160 children with SMPP were enrolled in the study.Using different treat-ment regimens,they were assigned to the control group and the observation group,80 cases in each group.The groups received conventional treatment and bronchoscopic alveolar lavage assisted conventional treatment,respectively.The duration of clinical symptoms,clinical efficacy,peripheral blood CRP and PCT levels,and complication rate were compared between the two groups.Results:Inter-group comparisons found that the duration of clinical symptoms was shorter in the observation group(P<0.05).The overall clinical effective rate was higher in the observation group(P<0.05).After 2 weeks of treatment,pe-ripheral blood CRP and PCT levels in both groups decreased(P<0.05),and the observation group was lower than the control group(P<0.05).The complication rate in the observation group was lower than that in the control group(3.75%vs.12.50%,P<0.05).Conclusion:Bronchoscopic alveolar lavage as an adjuvant therapy can achieve significant therapeutic effects on SMPP in children.It can shorten the duration of clinical symptoms,lower peripheral blood CRP and PCT levels,and reduce complication risk.

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郑丹丹;马金海;马小龙;黄捷;.支气管镜肺泡灌洗辅助治疗小儿重症肺炎支原体肺炎疗效及对外周血CRP、PCT水平的影响[J].川北医学院学报,2025,40(11):1390-1393.

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  • 在线发布日期: 2025-12-22
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