Objective:To investigate the influence of different doses of esomeprazole during bismuth quadruple regimen on the eradication rate of Helicobacter pylori(Hp)and the levels of serum gastrointestinal hormones and interleukin-17(IL-17)levels in patients with peptic ulcer.Methods:A total of 122 patients with Hp infection and peptic ulcer were enrolled,and they were treated with bismuth quadruple therapy.According to different treatment plans(high and low doses of esomeprazole),pa-tients were divided into a high-dose group and a standard dose group,with 61 cases in each group.The clinical efficacy,Hp erad-ication rate,serum gastrointestinal hormones and inflammatory indexes before and after treatment and adverse drug reactions were compared between the two groups.Results:The clinical efficacy in high-dose group was higher than that in the standard-dose group(P<0.05).PP analysis and ITT analysis showed that the eradication rate of Hp in the high-dose group was higher than that in the standard-dose group(P<0.05).After treatment,serum gastrin,IL-17,IL-6 and CRP levels in the two groups were decreased(P<0.05)while serum motilin level was increased(P<0.05),and the gastrin,IL-17,IL-6 and CRP levels in the high-dose group were lower than those in the standard-dose group(P<0.05)while the motilin level was higher than that in the standard-dose group(P<0.05).There was no statistical difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application of high-dose esomeprazole at a dose of 40 mg/time in the bismuth quadrup-le therapy for the treatment of peptic ulcers is more effective than the standard dose of esomeprazole at a dose of 20 mg/time,with higher Hp eradication rate and higher safety,and has clinical application value.