Objective:To compare the clinical effect of chest-breast and subclavian approach endoscopic treatment of unilat-eral thyroid carcinoma.Methods:Clinical data of 105 patients undergoing endoscopic thyroid surgery from March 2022 to Au-gust 2024 were retrospectively analyzed.According to the surgical methods,they were divided into thoracic breast approach en-doscopic thyroid surgery group(n=50)and subclavian approach endoscopic thyroid surgery group(n=55).The general condi-tion,operation related indexes and 3 months follow-up of the two groups were analyzed statistically by χ2 test,t test,Mann-Whitney test and CUSUM learning curve chart.Results:There were no significant differences in tumor size(7.28±4.73)vs.(7.36±4.40)mm,number of lymph nodes cleared(6.12±3.67)vs.(6.76±4.44),number of lymph node metastasis(1.88±2.67)vs.(1.15±1.75),postoperative cosmetic satisfaction between chest-breast and subclavian approach groups(P>0.05).There was significant difference in age(33.82±6.06)vs.(40.24±11.35)years old,time of operation(123±17.04)vs.(100.35±22.08)min and postoperative neck function(P<0.05).Conclusion:Transthoracic and subclavian endoscopic thy-roid surgery are both safe and feasible,with the same aesthetic satisfaction of incision.The operation time is short and the oper-ation is easy to master through the subclavian approach,and the cervical function is better protected through the natural muscle space approach of the side neck.