Objective:To explore the efficacy of iroot SP and AH-Plus during root canal therapy.Methods:130 patients with pulpitis and periapical periodontitis were divided into iroot SP group(n=66,77 teeth)and AH-Plus group(n=66,75 teeth)by different treatment regimens.All affected teeth were mechanically prepared to F2 using protaper gold under the rub-ber barrier,and performed root canal filling after chemical preparation with 1%sodium hypochlorite solution,and the iroot SP group used iroot SP+hot gutta-percha vertical condensation,and the AH-Plus group adopted AH-Plus+hot gutta-percha verti-cal condensation.All patients were followed up for 3 months after treatment.The clinical efficacy,percussion pain and occlusal pain occurrence,root filling density(number of void area,percentage of void area),and periodontal conditions(gingival sulcus bleeding index score and dental plaque index score)were compared between the two groups.Results:After treatment,the total effective rate revealed no statistical significance between groups(P>0.05).The incidence rates of percussion pain and occlusal pain in iroot SP group were lower than those in AH-Plus group(P<0.05).The scores of gingival sulcus bleeding index and plaque index in the two groups were reduced(P<0.05),and the above scores were lower in iroot SP group than those in AH-Plus group(P<0.05).There was no statistical significance in the number of void area and percentage of void area between iro-ot SP group and AH-Plus group(P>0.05).Conclusion:Both iroot SP and AH-Plus root canal filling show good clinical effica-cy and root filling fitting.Compared with AH-Plus,iroot SP root canal filling therapy can more effectively relieve the percussion pain and occlusal pain of patients with dental pulp disease,and improve the periodontal conditions.