Objective: To explore the clinical application value of Da Vinci robot or traditional laparoscopic distal radical resection in the treatment of gastric cancer based on propensity score matching. Methods: The medical records of patients with gastric cancer who received distal radical resection of gastric cancer were collected. According to the different surgical methods, they were divided into robot group (Da Vinci robotic surgery, n = 85) and laparoscopic group (traditional laparoscopic surgery, n = 81). Propensity score matching (1:1 nearest neighbor matching, caliper value of 0.2) was used to balance the baseline data. Finally, 63 pairs of data in each group were obtained. Both groups were followed up for 6 months after surgery. The perioperative indexes (surgical time, number of lymph node dissection, postoperative first liquid diet time, abdominal drainage volume, postoperative first anal exhaust time, postoperative ambulation time, postoperative hospital stay), inflammatory factors [C-reactive protein (CRP), procalcitonin (PCT), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), white blood cell count (WBC)], tumor markers [cancer antigen 19-9 (CA19-9), carcinoembryonic antigen (CEA)], postoperative complications, and recurrence rate were compared between the two groups. Results: After treatment, the number of lymph node dissection, postoperative first anal exhaust time, abdominal drainage volume, and postoperative ambulation time in the robot group were better than those in the laparoscopic group (P 0.05). Conclusion: Da Vinci robot surgery can improve surgical efficiency and lymph node dissection efficacy, and reduce the postoperative inflammatory response, and it does not increase postoperative risk.