Objective: Leveraging mobile health (mHealth) technology, to examine the risk factors of type Ⅱ diabetes mellitus to painful diabetic peripheral neuropathy (PDPN). Methods: Based on the presence of PDPN, the 102 type 2 diabetic patients were split into two groups: 30 were lesioned and 72 were not. Age, gender, duration of diabetes, body mass index (BMI), fasting blood glucose, glycated hemoglobin, and triglycerides were among the clinical data gathered. Patient satisfaction with the mHealth intervention, adherence to the mHealth intervention, frequency of use, and duration of use were among the data pertaining to mHealth applications. The independent risk factors of PDPN in type 2 diabetes patients were analyzed by comparing the differences of various indicators between the two groups. ROC prediction curves were plotted to evaluate each risk factor’s predictive value for PDPN. Results: Significant between-group disparities were observed in fasting plasma glucose, glycosylated hemoglobin, triglycerides, mHealth usage frequency, and duration (P 0.75, especially glycosylated hemoglobin (0.887) and mHealth usage frequency (0.879) with prominent efficiency. Conclusion: Controlling the levels of glycosylated hemoglobin and triglycerides and increasing the frequency and duration of mHealth usage can reduce the risk of PDPN.