Objective: To explore the clinical outcomes of using modified Buyang Huanwu Decoction alongside acupuncture in treating post-stroke Qi deficiency and blood stasis syndrome in cerebral infarction patients. Methods: A retrospective analysis was conducted on 102 patients with Qi deficiency and blood stasis syndrome after cerebral infarction. The patients were divided into two groups based on treatment methods: the control group (receiving conventional treatment + acupuncture, n=51) and the observation group (receiving Buyang Huanwu Decoction with modifications in addition to the treatment in the control group, n=51). Both groups were treated for 4 weeks. The clinical efficacy, Traditional Chinese Medicine (TCM) syndrome scores before and after treatment, Barthel Index, muscle strength grading, Water Swallowing Test (WST) grading, coagulation function, and safety were compared between the two groups. Results: The observation group achieved a higher overall effectiveness rate than the control group (P0.05). Conclusion: Modified Buyang Huanwu Decoction combined with acupuncture can improve clinical symptoms, muscle strength, swallowing ability, daily living capacity, and coagulation function in patients with post-stroke Qi deficiency and blood stasis syndrome, without increasing the incidence of adverse reactions.