Objective: To investigate the clinical efficacy of supplementing vitamins A and D in the treatment of preeclampsia (PE) patients with gestational hypertension. Methods: 86 patients with gestational hypertension and PE were enrolled and divided into a control group (n=43, 50.0%) and a study group (n=43, 50.0%) based on different treatment regimens. The control group received magnesium sulfate + nifedipine for blood pressure control and seizure prophylaxis, while the study group received additional vitamin A and D as adjunctive therapy alongside magnesium sulfate and nifedipine. Changes in blood pressure, catecholamine levels, and inflammatory/endothelial factors were compared between the two groups before and after treatment. Results: After treatment, both groups of PE patients showed a decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) compared to before treatment (P<0.05). The post-treatment systolic blood pressure (142.52±9.41) mmHg and diastolic blood pressure (90.40±8.11) mmHg in the study group were significantly lower than those in the control group (158.01±10.32) mmHg and (98.31±9.22) mmHg, respectively (P<0.05). After treatment, dopamine, norepinephrine, and epinephrine levels decreased significantly in both groups of PE patients compared to before treatment (P<0.05), with the study group was lower than the control group (P <0.05). After treatment, tumor necrosis factor-α (TNF-α), endothelin-1 (ET-1), and C-reactive protein (CRP) levels decreased significantly in both groups of PE patients compared to before treatment (P<0.05), with the study group was lower than the control group (P<0.05). Vascular endothelial growth factor (VEGF) and placental growth factor (PLGF) levels increased significantly in both groups after treatment compared to before treatment (P<0.05), with the study group was higher than the control group (P<0.05). Conclusion: Supplementation with vitamins A and D, in addition to conventional anticonvulsant and antihypertensive therapy, significantly reduces blood pressure and catecholamine levels, and improves inflammatory and endothelial factor levels in patients with gestational hypertension and PE.