Objective: To analyze the influence of combination of Yiqi Yangyin Huatan Quyu method and methimazole on glucolipid metabolism and thyroid hormones levels in patients with hyperthyroidism. Methods: 196 patients with hyperthyroidism were included and categorized into routine group and combined group, with 98 cases in each group. The routine group was treated with methimazole, whereas the combined group received Yiqi Yangyin Huatan Quyu decoction combined with methimazole. Both groups were treated continuously for 1 months. The TCM symptoms scores (anterior neck enlargement, palpitations, irritability, polyphagia and polydipsia), glucolipid metabolism [2 h postprandial blood glucose (2hPG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C)] and thyroid hormones [free thyroxine T3 (FT3), free thyroxine T4 (FT4), total triiodothyronine (TT3), total thyroxine (TT4), thyroid stimulating hormone (TSH)] before and after treatment and total incidence rate of adverse drug reactions (allergic dermatitis, gastrointestinal reaction, leukopenia) during treatment were compared between both groups of patients. Results: After treatment, the scores of TCM syndromes and levels of 2hPG, FT3, FT4, TT3 and TT4 in the two groups were decreased, and the combined group had lower scores of TCM syndromes such as palpitations, irritability, and polyphagia and polydipsia as well as lower FT3 and TT3 levels (P0.05). The levels of TC, LDL-C and TSH were increased in both groups, and the levels in combined group were higher (P0.05). Conclusion: Yiqi Yangyin Huatan Quyu method combined with methimazole has an exact effect in the treatment of patients with hyperthyroidism. Additionally, it can relieve clinical symptoms, and improve glucolipid metabolism and thyroid hormones, and it will not increase the risk of adverse drug reactions.